Objectives for Assessing the Repeated Dose Toxicity of a Substance

The general objectives for assessing the potential of a substance to induce repeated dose toxicity are to evaluate  

Whether exposure of humans to a substance has been associated with adverse toxicological effects occurring as a result of repeated daily exposure for a part of the expected lifetime or for the major part of the lifetime. 

Toxicological Risk Assessments of Chemicals A Practical Guide 

Whether individuals and/or subgroups in the population are more susceptible to general 

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