Obidoxime tabun poisoning

Kassa, J., Jun, D., Kuca, K. (2007). A comparison of reactivating efficacy of newly developed oximes (K074, K075) and currently available oximes (obidoxime, HI-6) in cyclosarin and tabun-poisoned rats. J. Enzyme Inhib. Med. Chem. 22 297-300. 

Kassa, J., Karasova, J., Musilek, K., Kuca, K. (2008). An evaluation of therapeutic and reactivating effects of newly developed oximes (K156, K203) and commonly used oximes (obidoxime, trimedoxime, HI-6) in tabun-poisoned rats and mice. Toxicology 243 311-16. 

Obidoxime and pralidoxime have been shown in animal studies to be effective against sarin and VX poisoning in different species but both are ineffective against cyclosaiin. Obidoxime has been shown to be superior to pralidoxime and HI-6 (a recently developed oxime used in the military setting) for tabun poisoning. 

Clement, J.G., Shiloff, J.D., and Gennings, C., Efficacy of the combination of acetylcholinesterase reactivators, HI-6 and obidoxime, against tabun and soman poisoning in mice, J. Chromatogr., 389, 87-94, 1987. 

As the A-alkylpyridine compounds are quaternary ammonium derivatives, it is likely that they exert their action mainly at peripheral nicotinic and muscarinic sites. Thus, organophosphate inhibition of the rat diaphragm may be reversed by these compounds in vitro [222], and Wolthuis and Meeter [223] showed neuromuscular blockade and inhibition of cholinesterase by DFP in vivo to be reversed by obidoxime and by PAM at the voluntary neuromuscular junction, but only very weakly in the brain. PAM and MINA also restore tetanus to the rat diaphragm in vitro after organophosphate exposure [224]. PAM is superior to both TMB-4 and obidoxime against soman poisoning whereas obidoxime is superior to PAM against tabun. Thus the effectiveness of the oxime varies with the cholinesterase inhibitor. 

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