Obidoxime combination therapy

In three studies reviewed by FAO/WHO (1994) on phosalone and 2-PAM methylsulfate in mice, P2S in rats, and obidoxime in mice, all appeared effective, although various aspects of the design of the. studies were not optimal. Oximes (PAM or obidoxime) in combination with atropine were successful in rats experimentally poisoned with pyrazophos, and there was some indication that repeated dosing was required for optimal antidotal efficacy (FAO/WHO, 1993). In a rat study of experimental terbufos poisoning, little benefit was observed from PAM and atropine (FAO/WHO, 1991). In rat studies on triazophos, combinations of atropine. sulfate and 2-PAMI or atropine sulfate and obidoxime were successful as experimental therapies (FAO/WHO, 1994). The effects of oximes in profenofas-poisoned chicks and mice were reported to be limited, as expected, although atropine was effective (FAO/WHO, 1991). 

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