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O,p-DDD

Mitotane (o,p-DDD) -adrenocortical cytotoxin -nausea and vomiting -CNS toxicity—lethargy, vertigo, sedation, dizziness -adrenal insufficiency—must use replacement doses of mineralocorticoids and glucocorticoids -diarrhea -fever -wheezing -flushing... [Pg.176]

Fig. 5 Main contamination sources identified by PCA for sediments, fish, and suface water in the Ebro River basin, and explained variances for each principal component. Variable identification. Organic compounds in sediments 1, summatory of hexachlorocyclohexanes (HCHs) 2, summa-tory of DDTs (DDTs) 3, hexachlorobenzene (HCB) 4, hexachlorobutadiene (HCBu) 5, summatory of trichlorobenzenes (TCBs) 6, naphthalene 7, fluoranthene 8, benzo(a)pyrene 9, benzo(b) fluoranthene 10, benzo(g,h,i)perylene 11, benzo(k)fluoranthene 12, indene(l,2,3-cd)pyrene. Organic compounds in fish 1, hexachlorobenzene (HCB) 2, summatory of hexachlorocyclohexanes (HCHs) 3, o,p-DDD 4, o,p-DDE 5, o,p-DDT 6, p,p-DDD 7, />,/>DDE 8, />,/>DDT 9, summatory of DDTs (DDTs) 10, summatory of trichlorobenzenes (TCBs) 11, hexachlorobutadiene (HCBu) 12, fish length. Physico-chemical parameters in water 1, alkalinity 2, chlorides 3, cyanides 4, total coliforms 5, conductivity at 20°C 6, biological oxygen demand 7, chemical oxygen demand 8, fluorides 9, suspended matter 10, total ammonium 11, nitrates 12, dissolved oxygen 13, phosphates 14, sulfates 15, water temperature 16, air temperature... Fig. 5 Main contamination sources identified by PCA for sediments, fish, and suface water in the Ebro River basin, and explained variances for each principal component. Variable identification. Organic compounds in sediments 1, summatory of hexachlorocyclohexanes (HCHs) 2, summa-tory of DDTs (DDTs) 3, hexachlorobenzene (HCB) 4, hexachlorobutadiene (HCBu) 5, summatory of trichlorobenzenes (TCBs) 6, naphthalene 7, fluoranthene 8, benzo(a)pyrene 9, benzo(b) fluoranthene 10, benzo(g,h,i)perylene 11, benzo(k)fluoranthene 12, indene(l,2,3-cd)pyrene. Organic compounds in fish 1, hexachlorobenzene (HCB) 2, summatory of hexachlorocyclohexanes (HCHs) 3, o,p-DDD 4, o,p-DDE 5, o,p-DDT 6, p,p-DDD 7, />,/>DDE 8, />,/>DDT 9, summatory of DDTs (DDTs) 10, summatory of trichlorobenzenes (TCBs) 11, hexachlorobutadiene (HCBu) 12, fish length. Physico-chemical parameters in water 1, alkalinity 2, chlorides 3, cyanides 4, total coliforms 5, conductivity at 20°C 6, biological oxygen demand 7, chemical oxygen demand 8, fluorides 9, suspended matter 10, total ammonium 11, nitrates 12, dissolved oxygen 13, phosphates 14, sulfates 15, water temperature 16, air temperature...
Mitotane, or o,p -DDD, is an oral medication used in the treatment of adrenocortical carcinoma. Chemically it is an isomere of DDT. Following its metabolism in the adrenal cortex to a reactive acyl chloride intermediate, mitotane covalently binds to adrenal proteins, specitically inhibiting adrenal cortical hormone production. The drug accumulates in fat tissue. It is eliminated mainly by the kidneys with a half-life of 18-159 days. Common side effects include anorexia, nausea, lethargy, sleepiness and skin problems. [Pg.462]

Hexane a-BHC, y-BHC, o,p -DDD, p.p -DDD, Dieldrin, Endrin, Heptachlor, Heptachlor epoxide Electron capture detection [100]... [Pg.272]

FIGURE 18.1.1.21.1B Logarithm of mole fraction solubility (In x) versus reciprocal temperature for o p -DDD. [Pg.590]

Figure 4.1 Structures ofo,p -DDT, o,p -DDD, and toxaphene congener B8-1412 [256], Only one enantiomer of each compound is depicted. Absolute configuration of chiral DDT components from Reference [3 I]... Figure 4.1 Structures ofo,p -DDT, o,p -DDD, and toxaphene congener B8-1412 [256], Only one enantiomer of each compound is depicted. Absolute configuration of chiral DDT components from Reference [3 I]...
Robinson BG, Hales IB, Henniker AJ, et al. 1987. The effect of o- p -DDD on adrenal steroid replacement therapy requirements. Clin Enodcrinol 27 437- 444. [Pg.88]

Over the last decades, large amounts of different man-made chemicals which can act as weak estrogens have been released into the terrestrial and aquatic environment and are distributed world-wide. Classical environmental estrogens are pesticides, such as o,p -DDT, and its metabohtes o,p -DDE and o,p -DDD, methoxychlor and its metabolites, chlordecone (Kepone ), dieldrin, Toxaphene, and endosulfan [126, 135, 136]. It is also known that many chemicals with very weak or no measurable estrogenic activity can be metabolized in organisms especially to hydroxylated compounds which may have much more estrogenic potency than the parent compound. Examples are methoxychlor and its mono- and di-demethylated derivatives [126,127] as well as the alkylphenol... [Pg.33]

The adrenocorticolytic drug mitotane (o,p -DDD), used in dogs and humans to treat adrenocortical hyperplasia, is of no therapeutic benefit in the treatment of ECD in horses. [Pg.80]

Mitotane (o,p -DDD Lysodren-Bristol-Myers Squibb Oncology)... [Pg.399]

See other pages where O,p-DDD is mentioned: [Pg.166]    [Pg.21]    [Pg.183]    [Pg.420]    [Pg.146]    [Pg.347]    [Pg.351]    [Pg.205]    [Pg.212]    [Pg.196]    [Pg.196]    [Pg.197]    [Pg.1523]    [Pg.319]    [Pg.639]    [Pg.721]    [Pg.57]    [Pg.57]    [Pg.59]    [Pg.39]    [Pg.272]    [Pg.586]    [Pg.587]    [Pg.589]    [Pg.590]    [Pg.795]    [Pg.800]    [Pg.158]    [Pg.1541]    [Pg.73]    [Pg.182]    [Pg.267]    [Pg.2363]    [Pg.166]    [Pg.80]    [Pg.144]    [Pg.145]   
See also in sourсe #XX -- [ Pg.263 ]

See also in sourсe #XX -- [ Pg.48 ]



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