Nystatin antifungal action

Triamcinolone Nystatin (Mycolog ) [Anti-inflammatory Antifungal/Corticosteroid] Uses Cutaneous candidiasis Action Antifungal anti-inflammatory Dose Apply lightly to area bid max 25 mg/d Caution [C, ] Contra Varicella systemic fungal Infxns Disp Cream oint SE Local irritation, hypertrichosis, pigmentation changes Interactions T Effects W/barbiturates, phenytoin, rifampin T effects OF salicylates, vaccines EMS See Triamcinolone OD See Triamcinolone... 

Nystatin (Mycostatin) is a polyene antifungal drug with a ring structure similar to that of amphotericin B and a mechanism of action identical to that of amphotericin B. Too toxic for systemic use, nystatin is limited to the topical treatment of superficial infections caused by C albicans. Infections commonly treated by this drug include oral candidiasis (thrush), mild esophageal candidiasis, and vaginitis. 

Nystatin was discovered in 1950 and exhibits the same mode of action as amphotericin B but tends to be of lower solubility, which has restricted its use to the treatment of topical infections. While nystatin was effective for the treatment of conditions such as oral and vaginal candidosis its use has been overtaken by the introduction of azole antifungal drugs. 

Amphoteridn is a complex amphoteric polyene antibiotic that binds to cell membranes and forms a pore through which ions can pass, with consequences that include loss of potassium ions from within the cell. Since the antibiotic binds more readily to fungal cell membranes than mammalian, its action is relatively selective. It can potentiate the action of certain other antifungals. and it may be used with flucytosine. Also, it confers antifungal activity on rifampicin (normally antibacterial). As it has an appreciable renal toxicity, it needs to be used with caution in some patients. Nystatin is a polyene antibiotic similar in structure to amphotericin, often used for local treatment. 

---