Nucleotide regulation

Synthesized by soluble guanylyl cyclase and particulate guanylyl cyclase from guanosine triphosphate (GTP). Nitric oxide activates soluble guanylyl cyclase to enhance cyclic GMP production that contributes to various NO actions. Cyclic GMP is hydrolyzed by phosphodiesterases. Cyclic GMP binds to and activates cGMP-dependent protein kinase, phosphodiesterases, and Cyclic Nucleotide-regulated Cation Channels. 

In cyclic nucleotide-regulated channels, this domain serves as a high-affinity binding site for 3-5 cyclic monophosphates. The CNBD of channels has a significant sequence similarity to the CNBD of most other classes of eukaryotic cyclic nucleotide receptors and to the CNBD of the prokaryotic catabolite activator protein (CAP). The primary sequence of CNBDs consists of approximately 120 amino acid residues forming three a-helices (oA-aC) and eight (3-strands ( 31- 38). 

Cyclic Nucleotide-regulated Cation Channels Cyclic Guanosine Monophosphate... 

Mattera, R., Pitts, B. J., Entman, M. L., and Bimbaumer, L. (1985) Guanine nucleotide regulation of a mammalian myocardial muscarinic receptor system. Evidence for homo-and heterotropic cooperativity in ligand binding analyzed by computer-assisted curve fitting. J. Biol. Chem. 260,7410-7421. 

Hofmann F, Biel M, Kaupp UB (2005) International Union of Pharmacology. LI. Nomenclature and structure-function relationships of cyclic nucleotide-regulated channels. Pharmacol Rev 57 455-62... 

Cyclic nucleotide regulated protein kinase family = Adenylyl cyclases = A-kinase anchor proteins = Atypical PKCs = Atrial natriuretic peptide = Adenosine 5 -triphosphate = Brain natriuretic peptide = Ca Vcalmodulin-dependent kinases = Cyclin-dependent kinases = Ca -dependent protein kinase = Casein kinase I = Casein kinase II = Dcd-like kinase... 

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