Nucleoside 2 ,3 -phosphates organic esters

In addition to ATP and other nucleoside triphosphates, cells use a variety of other organic phosphate compounds in energy metabolism. These include acetyl phosphate, glyc-erate-l,3-bisphosphate, phosphoenolpyruvate, phosphocre-atine, and phosphoarginine. Figure 2.9 shows the structures of these compounds and some simpler phosphate esters. The... 

Enterobacteria aerogenes can be grown when dimethyl phosphate is the sole source of phosphorus, and under these conditions a phosphodiesterase can be isolated from the micro-organism which utilizes dialkyl esters of phosphoric acid as substrates. Phosphodiesterases which have been isolated hitherto utilize nucleoside 2, 3 - or 3, 5 -phosphates and 4-nitrophenyl esters as substrates. A studyhas confirmed the hypothesis that phosphate binds to uridine phosphorylase before uridine, and that uracil leaves the enzyme before ribose-1 -phosphate. 

Phosphodiester a phosphate ester in which two hydroxyl groups of the phosphoric acid are esterified with organic residues RO-PO2H-OR. For example, R and R may be nucleosides. All polynucleotides and nucleic adds are R, in which the 3 and 5 positions of neighboring pentose units are linked by esterification with a phosphate residue. 

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