Nuclear receptors defined

Marchese AM et al. Discovery of three novel orphan G-protein-coupled receptors. Genomics 1999 56 12-21. Bertilsson G et al. Identification of a human nuclear receptor defines a new signaling pathway for CYP3A induction. Proc Natl Acad Sci USA 1998 95 12208-12213. 

Bertilsson, G., Heidrich, J., Svensson, K., Asman, M., Jendeberg, L., Sydow-Backman, M., Ohlsson, R., Postlind, H., Blomquist, P. and Berkenstam, A. (1998) Identification of a human nuclear receptor defines a new signaling... 

Ohlsson, H. Postlind, P. Blomquist, and A. Berkenstam, Broc. Natl. Acad. Set. U.S.A., 95, 12208 (1998). Identification of a Human Nuclear Receptor Defines a New Signaling Pathway for CYP3A Induction. 

Rosenfeld, J.M., Vargas, R., Jr, Xie, W. and Evans, R.M. (2003) Genetic profiling defines the xenobiotic gene network controlled by the nuclear receptor pregnane X receptor. Molecular Endocrinology, 17, 1268-1282. 

Kliewer SA, Moore JT, Wade L, Staudinger JL, Watson MA, Jones SA, McKee DD, Oliver BB, Willson TM, Zetterstrom RH, Perlmann T, Lehmann JM (1998) An orphan nuclear receptor activated by pregnanes defines a novel steroid signaling pathway. Cell 92 73-82... 

Under this framework. Fig. 6 shows the basic pieces for constructing annotated chemical libraries. On the one hand, proteins should be stored using the appropriate annotation under their respective protein-family classification schemes (in this case, nuclear receptors). On the other hand, molecules should be stored using a unique hierarchical identifier. The link between the two entities (molecules and proteins) would be defined by pharmacological data (activity). The use of a certain criteria would then allow to construct a binary annotation matrix, from which the mapping of the chemogenomic space is established. 

Kliewer SA, Moore JT, Wade L et al. An orphan nuclear receptor activated by pregnane defines novel steroid signaling pathway. Cell 1998 92 73-82. 

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