Nuclear magnetic resonance epoxidation reaction

Betso, J.E., Carreon, R.E. and Miner, V.M. (1991) The use of proton nuclear magnetic resonance spectrometry ( H NMR) for monitoring the reaction of epoxides with butylamine and predictive capabilities of the relative alkylation index (RAI) for skin sensitization by epoxides. Toxicol. Appl. Pharm., 108, 483—488. 

Many of the procedures already outlined for the preparation of halo-genated sugars involve the production of two or more isomers. Occasionally, the information required can be obtained from the reaction without isolation of the products. The direction of epoxide cleavage has been initially determined by periodate oxidation, before separation of the products. Similarly, the mixtures obtained by halogenation and halomethoxylation have been investigated by nuclear magnetic resonance, to find the nature of the products prior to isolation. - ... 

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