Deuterium nuclear magnetic resonance

The principal methods for deterrnination of the deuterium content of hydrogen and water are based upon measurements of density, mass, or infrared spectra. Other methods are based on proton magnetic resonance techniques (77,78), F nuclear magnetic resonance (79), interferometry (80), osmometry (81), nuclear reaction (82), combustion (83), and falling drop methods (84). 

Quadrupole coupling constants for molecules are usually determined from the hyperfine structure of pure rotational spectra or from electric-beam and magnetic-beam resonance spectroscopies. Nuclear magnetic resonance, electron spin resonance and Mossbauer spectroscopies are also routes to the property. There is a large amount of experimental data for and halogen-substituted molecules. Less data is available for deuterium because the nuclear quadrupole is small. 

Boulanger, Y. Schreier, S. Smith, I. C.P., Molecular detailsof anesthetic-lipid interaction as seen by deuterium and phosphorus-31 nuclear magnetic resonance, Biochemistry 20, 6824-6830 (1981). 

Other optical and spectroscopic techniques are also important, particularly with regard to segmental orientation. Some examples are fluorescence polarization, deuterium nuclear magnetic resonance (NMR), and polarized IR spectroscopy [4,246,251]. Also relevant here is some work indicating that microwave techniques can be used to image elastomeric materials, for example, with regard to internal damage [252,253]. 

Nuclear magnetic resonance may yield identification of histidine by deuterium exchange (N-H versus N-D) at or near the metal, especially if paramagnetic.252 The resonances are moved away from the 0-10 ppm region as a result of a paramagnetic center in proximity. 

Halcinonide dissolved in either methanol, deutero-methanol, aqueous ammonia-methanol, or deuterium oxide deuter-ated ammonia-methanol solvents appears stable after storage for six days at 50°, using nuclear magnetic resonance and mass spectrometry.70... 

The nuclear magnetic resonance spectrum of sodium valproate as shown in Figure 3 was obtained on a Varian Associates T-60 NMR Spectrometer in deuterium oxide containing tetramethylsilane as the internal standard. The spectral peak assignments (2) are presented in Table I. 

Vittadini, E., Dickinson, L.C., and Chinachoti, P. 2002. NMR water mobility in xanthan and locust bean gum mixtures Possible explanation of microbial response. Carbohydr. Polym. 49, 261-269. Wachner, A.M. and Jeffrey, K.R. 1999. A two-dimensional deuterium nuclear magnetic resonance study of molecular reorientation in sugar/water glasses. J. Chem. Phys. Ill, 10611-10616. Wagner, W. and Pruss, A. 1993. International equations for the saturation properties of ordinary water substance Revised according to the international temperature scale of 1990. J. Phys. Chem. Ref. Data 22, 783-787. 

Nuclear ion stopping, 74 433 Nuclear localization signal (NLS), 26 451 Nuclear magnetic resonance (nmr), 7 7 418 27 278. See also Deuterium nmr... 

Gangoda, M., Gilpin, R.K., and Figueirinhas, J., Deuterium nuclear magnetic resonance studies of alkyl modified silica, J. Phys. Chem., 93, 4815, 1989. 

Kamel AM, Zandi KS, Massefski WW. 2003. Identification of the degradation product of ezlopitant, a non-peptidic substance P antagonist receptor, by hydrogen deuterium exchange, electrospray ionization tandem mass spectrometry (ESI/MS/MM) and nuclear magnetic resonance (NMR) spectroscopy. J Pharm Biomed Anal 31 1211. 

Morrow et al. also examined the effects of pressure and temperature on DPPC and DMPC choline headgroup conformation using deuterium nuclear magnetic resonance. The electric dipole resulting from charge separation in... 

Nuclear magnetic resonance spectrometry. iH-nuclear magnetic resonance (NMR) spectra of samples in deuterium oxide were run at 500 MHz (IV and V-2) with a Bruker AMX-500 and at 300 MHz (V-2 and D,L-hydrox-ylysine) with a Gemini-300 (Varian) with the HOD signal at 8 4.8 ppm. 

The C-NMR spectrum ofindinavir sulfate, shown in Figure 13, was obtained using a Bruker Instruments model AMX-400 nuclear magnetic resonance spectrometer operating at a frequency of 100.55 MHz as an approximate 4.16 % w/v solution in deuterium oxide. The 67.4 ppm resonance of dioxane was used as an external reference standard. Peak assignments are found in Table 8, and make use of the numbered structural formula given previously [11]. 

The behavior of substituted benzenes does not afford adequate proof that benzene would behave in a similar way. There are two lines of evidence that it does (/) 1,3,5-trideuterobenzene isomerizes to benzenes with different deuterium distributions43 (the status of this work is at present not entirely satisfactory) and (2) benzvalene has been identified by nuclear magnetic resonance in liquid benzene exposed to ultraviolet light.41... 

F. Nuclear Magnetic Resonance Spectra and Deuterium Exchange 90... 

Primary amines may be readily distinguished from secondary and tertiary analogues by the presence of two absorption bands in the infrared spectrum between 3320 and 3500 cm-1 (symmetric and antisymmetric NH str.). Secondary amines exhibit a single absorption band at about 3350 cm-1 (NH str.). In both cases deformation modes for the NH bond appear at about 1600 cm-1. There is no satisfactory absorption to allow a definitive characterisation in the case of tertiary amines. In the nuclear magnetic resonance spectrum of primary and secondary amines, the nitrogen-bound hydrogens are recognisable by their replaceability on the addition of deuterium oxide. 

Giraudon, S., Danzart, M., and Merle, M. H. (2000). Deuterium nuclear magnetic resonance spectroscopy and stable carbon isotope ratio analysis/mass spectrometry of certain monofloral honeys.. AOAC Int. 83,1401-1409. 

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