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Nuclear hormone receptors development

Kostrouchova, M., Krause, M., Kostrouch, Z. and Rail, J.E. (1998) CHR3 a Caenorhabditis elegans orphan nuclear hormone receptor required for proper epidermal development and molting. Development 125,1617-1626. [Pg.197]

The KS mutations were identified in the KAL gene and result in abnormal olfactory bulb development (99,100). The mutations responsible for the X-linked IHH with adrenal hypoplasia congenita were identified in the DAXl gene. DAXl encodes an orphan nuclear hormone receptor that regulates portions of reproductive development (101,102). [Pg.124]

PSSC based reanalysis of the development of nuclear hormone receptor ligands... [Pg.73]

The farnesoid X receptor is a member of the class of nuclear hormone receptors, which have key roles in development and homeostasis, as well as in many diseases like obesity, diabetes and cancer. The farnesoid X receptor shows structural similarity to the estrogen receptor (ER ), which mediates a broad spectrum of physiological functions such as regulation of reproduction, modulation of bone density, cholesterol transport and breast cancer. The farnesoid X receptor also shows similarity with the peroxisome proliferation-activated receptor y (PPARy), which is involved in fat metabolism, inflammatory and immune responses. The estrogen receptor (ER ), the peroxisome proliferation-activated receptor y (PPARy) and the farnesoid X receptor (FXR) can be clustered in a... [Pg.74]

Hanley, K. etal. Activators of the nuclear hormone receptors PPAR and FXR accelerate the development of the fetal epidermal permeability barrier, J. Clin. Invest., 100, 705, 1987. [Pg.209]

Chapter 3 Assay Development for Nuclear Hormone Receptors.49... [Pg.285]

This technology is highly sensitive and DiscoveRx has developed several assays to measure cAMP [212], tyrosine or serine kinase [213], nuclear hormone receptors and proteases [214], as weU as assays for the measurement of cellular protein expression [211]. [Pg.649]

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