NPH insulin

NPH Isophane Human Insulin Suspension. NPH isophane insulin, also called Humulin N, Insulatard NPH Human, or Novolin N is an intermediate-acting form of human insulin produced by recombinant DNA techniques. Mixtures Humulin 70/30 and Novolin 70/30 contain 70% NPH isophane and 30% regular, whereas Humulin 50/50 contains 50% NPH isophane and 50% regular. It is adrninistered subcutaneously and should not be given intravenously. Absorption is delayed because the insulin is conjugated with protamine in a complex of reduced isoelectric solubiUty. Therapeutically, this preparation is probably comparable to purified porcine NPH insulin. However, human NPH insulin may have a slightly shorter duration of action than comparable purified porcine products. [Pg.340]

METHODS OF ADMINISTERING INSULIN. Several methods can be used to administer insulin. The most common method is the use of a needle and syringe Use of microfine needles has reduced the discomfort associated with an injection. Another method is the jet injection system, which uses pressure to deliver a fine stream of insulin below the skin. Another method uses a disposable needle and special syringe The syringe uses a cartridge that is prefilled with a specific type of insulin (eg, regular human insulin, isophane [NPH] insulin, or a mixture of isophane and regular insulin). [Pg.494]

A patient is prescribed 40 units NPH insulin mixed with 5 units of regular insulin. What is the total insulin dosage Draw a line on the syringe below showing the total insulin dosage. Describe how you would prepare the insulins. [Pg.509]

Previous protamine exposure (e.g., during coronary artery bypass graft, or NPH insulin products containing protamine zinc)... [Pg.98]

Neutral Protamine Hagedorn, better known as NPH insulin, is prepared by a process in which protamine is conjugated with... [Pg.658]

NPH insulin can be mixed with regular insulin and used immediately or stored for future use up to 1 month at room temperature or 3 months in refrigeration. NPH insulin can be mixed with either aspart or lispro insulins, but it must be injected immediately after mixing. Whenever mixing insulin products with NPH insulin, the shorter-acting insulin should be drawn into the syringe first. [Pg.658]

NPH insulin 20 units before breakfast and 5 units before... [Pg.808]

Glargine and detemir are long-acting peakless human insulin analogs that result in less nocturnal hypoglycemia than NPH insulin when given at bedtime. [Pg.227]

Use with insulin Repaglinide is not indicated for use in combination with NPH-insulin. [Pg.280]

ISOPHANE INSULIN SUSPENSION (NPH insulin combined with protamine and zinc) ... [Pg.289]

Decrease his morning regular insulin Decrease his morning NPH insulin Stop evening insulin and add a sulfonylurea at bedtime... [Pg.776]

Have him eat a larger lunch Move his evening NPH insulin from supper time to bedtime... [Pg.776]

Hypersensitivity reaction (urticaria, angioedema) nausea and vomiting, which generally occur in those sensitive to fish and seafood, vasectomized men, infertile men, those on isophane (NPH) insulin, or those previously on protamine therapy Rare Back pain... [Pg.1049]

Mixed (regular/NPH) insulin (10/90) biosynthetic insulin (20/80) biosynthetic insulin (30/70) biosynthetic... [Pg.605]

Isophane or Neutral Protamine Hagedorn (NPH) insulin (HUMINSULIN-N) 40 lU/ml SC... [Pg.276]

Lepore, M., S. Pampanelli, C. FanelU, F. Forcellati, L. Bartocci, A. Di Vincenzo, C. Cordoni, E. Costa, P. Brunetti, and G.B. Bolli, Pharmacokinetics and pharmacodynamics of subcutaneous injection of long-acting human insulin analog glargine, NPH insulin, and ultralente human insulin and continuous subcutaneous infusion of insulin lispro. Diabetes, 2000. 49(12) 2142-8. [Pg.215]

E Role in therapy Insulin glargine is as effective as human isophane (NPH) insulin suspension in patients with type 1 or 2 diabetes and is associated with a lower incidence of nocturnal hypoglycemia in some patients. [Pg.221]

NPH Insulin Neutral Protamine Hagedorn Insulin equivalent to isophane insulin... [Pg.536]

Extent and duration of action of various types of insulin as indicated by the glucose infusion rates (mg/kg/min) required to maintain a constant glucose concentration. The durations of action shown are typical of an average dose of 0.2-0.3 U/kg. The durations of regular and NPH insulin increase considerably when... [Pg.934]

NPH insulin is an intermediate-acting insulin whose absorption and the onset of action are delayed by combining appropriate amounts of insulin and... [Pg.935]

Heinemann L et al Time action profile of the long-acting insulin analog insulin glargine (HOE901) in comparison with those of NPH insulin and placebo. Diabetes Care 2000 23 644. [PMID 10834424]... [Pg.951]

Insulin, Human Isophane Suspension Insulin, Human NPH Insulin, Human Regular... [Pg.95]

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