Reagents novel

In the future, further studies should be addressed to improve the chemose-lectivity and diastereoselectivity of the reductive coupling process, especially searching for novel reagents and milder experimental conditions. As a matter of fact, a few novel reductive couphng procedures which showed improved efficiency and/or stereoselectivity have not been further apphed to optically active imines. For example, a new electrochemical procedure which makes use of the spatially addressable electrolysis platform with a stainless steel cathode and a sacrificial aluminum anode has been developed for imines derived from aromatic aldehydes, and the use of the N-benzhydryl substituent allowed 1,2-diamines to be obtained with good yields and dl-to-meso ratios... 

Forster, A.C., Mclnnes, J.L., Skingle, D.C., and Symons, R.H. (1985) Non-radioactive hybridization probes prepared by the chemical labeling of DNA and RNA with a novel reagent, photobiotin. Nucleic Acid Res. 13, 745-761. 

Gershoni, J.M., Bayer, E.A., and Wilchek, M. (1985) Blot analysis of glycoconjugates Enzyme-hydrazide— A novel reagent for the detection of aldehydes. Anal. Biochem. 146, 59-63. 

Thevenin, B., Shahrokh, Z., Williard, R., Fujimoto, E., Ikemoto, N., and Shohet, S. (1991) A novel reagent for functionally-directed site-specific fluorescent labeling of proteins, Abstract. Biophys. J. 59, Tu-Pos 476, p. 358a. 

G Galavema, R Corradini, A Dossena, R Marchelli. Diaminomethane dihydrochloride, a novel reagent for the synthesis of primary amides of amino acids and peptides from active esters. Int J Pept Prot Res 42, 53, 1993. 

Richardson also devised many novel reagents and chromogenic substances that are now used in various diagnostic kits of value for the rapid and accurate visual detection of human disease, as well as for the identification of pathogenic organisms associated with disease. For chemical posterity, it is therefore considered important to present a detailed account of Richardson s numerous research contributions. 

Marcantoni E, Nobili F, Bartoli G, Bosco M, Sambri L (1997) Cerium(III) chloride, a novel reagent for nonaqueous selective conversion of dioxolanes to carbonyl compounds. J Org Chem 62 4183 1184... 

N. Satyamurthy, G.T. Bida, M.E. Phelps, J.R. Barrio, Fluorine-18 labeled N-[ F] fluoro-N-alkylsulfonamides Novel reagents for mild and regioselective radiofluorina-tion, Appl. Radiat. Isot. 41 (1990) 733-738. 

Lamture, J. B. Wensel, T. G. A novel reagent for labeling macromolecules with intensely luminescent lanthanide complexes. Tetrahedron Lett. 1993, 34, 4141—4144. 

The approach taken to achieve these goals was to first select a set of novel reagents, then react these compounds with simple reagents to cap the reactive functionalities. Virtual products for the selected compounds were created and are then passed through an in silico filtering process. Finally, the filtered libraries were synthesized via combinatorial libraries. 

P. J. Garegg and B. Samuelsson, Novel reagent system for converting a hydroxy-group into an iodo-group in carbohydrates with inversion of configuration, J. Chem. Soc. Chem. Common. p. 978 (1979). 

R. Herranz, J. Castro-Picliel, and T. Garcia-Ldpez, Tributyltin cyanide, a novel reagent for the stereoselective preparation of 3-amino-2-hydroxy acids via cyanohydrin intermediates, Synthesis p. 703 (1989). 

K. Sato, K. Suzuki, M. Uead, M. Katayama, and Y. Kajihara, A novel reagent for the synthesis of branched-chain functionalized sugars, dichloromethyllithium, Chan. Lett. p. 1469 (1991). 

J. S. Yadav, B. V. S. Reddy, K. Bhaskar Reddy, and M. Satyanarayana, CeCl3 7HzO A novel reagent for the synthesis of 2-deoxysugars from D-glycals, Tetrahedron Lett., 43 (2002) 7009-7012. 

Yazynina et al. (1999) introduced novel reagents into the inhibition step with the goal of decreasing the long analysis times typically required for ELISA measurements. A polyanion-protein A conjugate was introduced into the atrazine antibody-enzyme conjugate solution. Antibody bound by protein A was in turn bound to the walls of a microplate coated with a polycation. This innovation reduced overall time of analysis to 40 min and achieved a detection limit of 0.03 ppb of atrazine. 

Section II,D. Reaction between Hg(SiMe3)2 and (Cp)2ZrCl2 gives Me3SiZr(Cp)2Cl and (Me3Si)2Zr(Cp)2 (434). Also, the novel reagent... 

Claisen rearrangement of aUylic alcohols to ethyl dienoates. Claisen rearrangement of allylic alcohols with an orthoacetate is known to provide 2-carbon homologated y,8-unsaturated esters (6, 607-608). Reaction with the phenylsulfinylorthoacetate 1 is accompanied by an in situ sulfoxide elimination to provide 2-carbon homologated dienoate esters (equation I). This novel reagent was used to convert the... 

Two novel reagents for the selective sulfonation of styrene to the (3-sultone (49) are reported (94ZOR948). The action of sulfur trioxide on the olefin CF2 CFS03SiMe3, yields the p-sultone (50) (94JFC89). 

The versatility of the novel reagent was investigated with a diverse selection of alcohols at room temperature with 3 equiv. of the reagent for 1 h. Results from the oxidations can be summarized as follows. Clean and rapid quantitative conversion to the respective aldehyde or ketone product was observed for all benzylic, allylic,... 

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