Quinidine Nortriptyline

Codeine, dextromethorphan, haloperidol, thioridazine, perphenazine, nortriptyline, desipramine, fluoxetine, norfluoxetine, TCAs (hydroxylation), beta-blockers such as timolol and metoprolol, type 1C antiarrhythmics encainide, flecainide TCAs (desmethylation), triazolam, alprazolam, midazolam, carbamazepine, terfenadine, quinidine, lidocaine, erythromycin, cyclosporin... 

Therapeutic plasma concentrations of TCAs have clinically significant antiarrhythmic activity (420). Imipramine and nortriptyline (and probably other TCAs) share electrophysiological properties characteristic of type I (A, B) compounds (e.g., quinidine, procainamide, disopyramide) and can even be used in cardiac patients free from depression, exclusively for the control of arrhythmia (421). 

Lipoproteins bind a small amount of certain drugs (imipramine, amitriptyline, nortriptyline, phenytoin, and quinidine), which usually bind to alpha,-acid glycoprotein. 

Figure 18-5. The separation of therapeutic tricyclic antidepressants on PBD-coated zirconia at different temperatures. Solutes 1, lidnocaine 2, quinidine 3, norephedrine 4, tryptamine 5, amitriptyline 6, nortriptyline. (Reproduced from reference 52, with permission. Copyright 1997, American Chemical Society.)...

Amitriptylline (B) Bupivacaine (B) Chlorpromazine (B) Diltiazem (B) Imipramine (B) Nortriptyline (B) Perazine (B) Propranolol (B) Quinidine (B)... 

Clinically important, potentially hazardous interactions with amiodarone, amitriptyline, amoxapine, benzodiazepines, bepridil, clomipramine, clonazepam, clorazepate, delavirdine, desipramine, diazepam, dihydroergotamine, doxepin, ergotamine, fentanyl, flurazepam, imipramine, ixabepilone, lidocaine, lorazepam, methysergide, midazolam, nortriptyline, oxazepam, phenytoin, protriptyline, quazepam, quinidine, rifampin, ritonavir, sildenafil, St John s wort, temazepam, tricyclic antidepressants, trimipramine, vitamin E... 

Clinically important, potentially hazardous interactions with amiodarone, amisulpride, amitriptyline, amoxapine, arsenic, bepridil, bretylium, calcium, chlorpromazine, clomipramine, desipramine, disopyramide, doxepin, erythromycin, fluphenazine, imipramine, iron salts, magnesium, mesoridazine, nortriptyline, pentamidine, perphenazine, phenothiazines, pimozide, procainamide, prochlorperazine, promazine, promethazine, protriptyline, quinidine, sotalol, sucralfate, thioridazine, tricyclic antidepressants, trifluoperazine, trimipramine, zinc salts... 

Simultaneous amitriptyline, caffeine, clomipramine, codeine, desipramine, etbotoin, imip-ramine, lidocaine, mesantoin, metbsuximide, nirvanol, nortriptyline, oxeizepam, propranolol, quinidine... 

Also analyzed acebutolol, acepromazine, acetaminophen, acetazolamide, acetophenazine, albuterol, amitriptyline, amobarbital, amoxapine, antipsrrine, atenolol, atropine, azata-dine, baclofen, benzocaine, bromocriptine, brompheniramine, brotizolam, bupivacaine, buspirone, butabarbital, butalbital, caffeine, carbamazepine, cetirizine, chlorqyclizine, chlordiazepoxide, chlormezanone, chloroquine, chlorpheniramine, chlorpromazine, chlorpropamide, chlorprothixene, chlorthalidone, chlorzoxazone, cimetidine, cisapride, clomipramine, clonazepam, clonidine, clozapine, cocaine, codeine, colchicine, qyclizine, (yclo-benzaprine, dantrolene, desipramine, diazepam, diclofenac, diflunisal, diltiazem, diphenhydramine, diphenidol, dipheno late, dipyridamole, disopyramide, dobutamine, doxapram, doxepin, droperidol, encainide, ethidium bromide, ethopropazine, fenoprofen, fentanyl, flavoxate, fluoxetine, fluphenazine, flurazepam, flurbiprofen, fluvoxamine, fii-rosemide, glutethimide, glyburide, guaifenesin, haloperidol, homatropine, hydralazine, hydrochlorothiazide, hydrocodone, hydromorphone, hydro g chloroquine, hydroxyzine, ibuprofen, imipramine, indomethacin, ketoconazole, ketoprofen, ketorolac, labetalol, le-vorphanol, lidocaine, loratadine, lorazepam, lovastatin, loxapine, mazindol, mefenamic acid, meperidine, mephenytoin, mepivacaine, mesoridazine, metaproterenol, methadone, methdilazine, methocarbamol, methotrexate, methotrimeprazine, methoxamine, methyl-dopa, methylphenidate, metoclopramide, metolazone, metoprolol, metronidazole, midazolam, moclobemide, morphine, nadolol, nalbuphine, naloxone, naphazoline, naproxen, nifedipine, nizatidine, norepinephrine, nortriptyline, oxazepam, oxycodone, oxymetazo-line, paroxetine, pemoline, pentazocine, pentobarbital, pentoxifylline, perphenazine, pheniramine, phenobarbital, phenol, phenolphthalein, phentolamine, phenylbutazone, phenyltoloxamine, phenytoin, pimozide, pindolol, piroxicam, pramoxine, prazepam, prazosin, probenecid, procainamide, procaine, prochlorperazine, procyclidine, promazine, promethazine, propafenone, propantheline, propiomazine, propofol, propranolol, protriptyline, quazepam, quinidine, quinine, racemethorphan, ranitidine, remoxipride, risperidone, salicylic acid, scopolamine, secobarbital, sertraline, sotalol, spironolactone, sulfinpyrazone, sulindac, temazepam, terbutaline, terfenadine, tetracaine, theophylline, thiethyl-perazine, thiopental, thioridazine, thiothixene, timolol, tocainide, tolbutamide, tolmetin, trazodone, triamterene, triazolam, trifluoperazine, triflupromazine, trimeprazine, trimethoprim, trimipramine, verapamil, warfarin, xylometazoline, yohimbine, zopiclone... 

Extracted desipramine, doxepin, imipramine, nortriptyline, protriptyline, trimipramipe Simultaneous atropine, butalbital, chlorpromazine, maprotUine, methadone, norpropo gr-phene, phenylpropanolamine, procainamide, prochlorperazine, promethazine, propranolol, quinidine, trifluoperazine, trimeprazine... 

Simultaneous N-acetylprocainamide, butaperazine, chlorimipramine, chlorpromazine, codeine, desipramine, dimethacrine, diphenhydramine, disop3rramide, doxepin, hydroquin-idine, maprotiline, melitracene, mesoridazine, nortriptyline, opipramol, perphenazine, procainamide, prochlorperazine, promazine, prothipendyl, protriptyline, quinidine, thiop-erazine, thioridazine, trifluoperazine... 

Extracted amoxapine, brompheniramine, chlorpheniramine, chlorpromazine, clomipramine, c5q)roheptadine, dsipramine, diphenhydramine, dothiepin, doxepin, fluoxetine, hal-operidol, imipramine, loxapine, maprotihne, meperidine, mesoridazine, methadone, metoclopramide, mianserin, moclobemide, nomifensine, nordoxepin, norfluoxetine, norpropoxyphene, northiaden, nortriptyline, pentobarbital, pheniramine, propojgrphene, propranolol, protriptyline, quinidine, quinine, sulforidazine, thioridazine, thiothixene, tranylcypromine, trazodone, trihe q)henidyl, triprolidine Nonintetfering dextromethorphan, norphetidine, pheno benzamine, prochlorperazine, trifluoperazine... 

Extracted acetaminophen, amobarbital, butabarbital, chlordiazepoxide, diazepam, eth-chlorvynol, flurazepam, glutethimide, methaqualone, methypiylon, nitrazepam, pentobarbital, phenobarbital, phenytoin, primidone, salicgrlic acid, secobarbital, theophylline Simultaneous amitriptyline, caffeine, clomipramine, codeine, desipramine, ethotoin, imip-ramine, lidocaine, mesantoin, methsuximide, nirvanol, nortriptyline, oxazepam, procainamide, phenylpropanolamine, propranolol, quinidine... 

Noninterfering acetaminophen, N-acetylprocainamide, amikacin, amitriptyline, clonazepam, cyclosporine, desipramine, diazepam, digoxin, disopyramide, gentamicin, p-hydrox- q>henobarbital, imipramine, Udocaine, methotrexate, netilmicm, nortriptyline, procainamide, quinidine, salicylic acid, sulfamethoxazole, tobramycin, trimethoprim, valproic add, vancomycin... 

Simultaneous amitriptyline, amobarbital, butalbital, carbamazepine, chlordiazepoxide, chlorpromazine, clonazepam, demoxepam, desipramine, diazepam, ethinamate, fluraze-pam, glutethimide, heptobarbital, hexobarbital, lidocaine, medazepam, meperidine, mephobarbital, mesoridazine, methaqualone, pentathal, nortriptyline, oxazepam, pentobarbital, perphenazine, phenytoin, promazine, propranolol, protriptyline, quinidine, secobarbital... 

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