Nortriptyline Foods

Clinically important, potentially hazardous interactions with amitriptyline, amoxapine, amphetamines, bupropion, citalopram, clomipramine, cyproheptadine, desipramine, dextroamphetamine, dextromethorphan, diethylpropion, dopamine, doxepin, entacapone, ephedrine, epinephrine, fluoxetine, fluvoxamine, imipramine, levodopa, mazindol, meperidine, methamphetamine, nefazodone, nortriptyline, paroxetine, phendimetrazine, phentermine, phenylephrine, phenylpropanolamine, pizotifen, protriptyline, pseudoephedrine, rizatriptan, sertraline, sibutramine, sumatriptan, sympathomimetics, tramadol, tricyclic antidepressants, trimipramine, tryptophan, tyramine-containing foods, venlafaxine, zolmitriptan... 

Liedholm H, Liden A. Food intake and the presystemic metabolism of single doses of amitriptyline and nortriptyline. Fundam Clin Pharmacol (1998) 12, 636-42. 

Metabolic inactivation, whether taking place in the e,r. or at other sites, is often accidentally inhibited by other drugs. Thus many patients have died as a result of the simultaneous administration of an inhibitor of monamine oxidase (an enzyme present in mitochondria) and an amine drug which is not toxic on its own. Thus the inhibitor phenelzine (9.36) (phenylethyl-hydrazine) has caused deaths after usually safe doses of amphetamine, pethidine, nortriptyline, or amitriptyline, or after the patient has consumed amine-rich food such as cheese, red wine, meat-extract, yeast-extract, or broad beans. These are examples of unfortunate synergism, but many favourable examples are known, examples of which will now be given. 

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