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Norharman comutagenic actions

The comutagenic action of Norharman upon aryl hydrocarbon hydroxylase activity is shown to be cytochrome P-448 dependent by immunochemical analysis. The hydroxylated products of Norharman and Harman may play an important role in their comutagenic action by fluidizing the microsomal or nuclear membranes. [Pg.99]

Comutagenic Action of Harman and Norharman When the reconstituted MFO system, which contained 3-MC induced cytochrome P-448, was used to study the effects of Norharman and Harman on the hydroxylation of Benzo(a)pyrene, they both showed an enhancement effect under the optimal enzymatic conditions. Norharman, however, showed a larger activity increase in Benzo(a)pyrene hydroxylation than Harman(Figure 5). It ascertains that the inhibitory effects of these carbolines on mutagenicity are not dependent on cytochrome P-448 in the sense of simple substrate inhibition. [Pg.108]

Norharman strongly enhanced the mutagenicity of DAB, but 3,4-dihy-dronorharman, 1,2,3,4-tetrahydronorharman, 9-methyl-j8-carboline, and 1,2,3,4-tetrahydroharman had no comutagenic action on DAB. The copresence of 7-carboline or 2-methyl-7-carboline exhibited the mutagenicity of o-toluidine. [Pg.54]

M. Nagao, T. Yahagi, M. Honda, Y. Seino, T. Kawachi, and T. Sugimura, Comutagenic actions of norharman derivatives with 4-dimethylaminoazobenzene and related compounds, Cancer Lett. 3, 339-346 (1977). [Pg.58]


See other pages where Norharman comutagenic actions is mentioned: [Pg.100]    [Pg.108]    [Pg.42]    [Pg.51]    [Pg.53]    [Pg.53]    [Pg.54]    [Pg.54]    [Pg.59]    [Pg.52]   
See also in sourсe #XX -- [ Pg.108 ]




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