Norfloxacin chromatography

Mizuni, A., Uematsu, T., Nakashima, M., Simultaneous Detection of Ofloxacin, Norfloxacin and Ciprofloxacin in Human Hair by High-Performance Liquid Chromatography and Fluorescence Detection, /. Chromatogr., 653, 187, 1994. [Pg.118]

Catalytic synthesis of l-ethyl>6-fluoro-l,4-dihydro-4-oxo-7-(l-piperazinyl)-quinoline-3-carboxylic acid ethyl ester (Norfloxacin ethyl ester) (15a). To a dry 15 mL recovery flask equipped with a reflux condenser was added 13 (150 mg, 0.5 mmole), (R)-binap (10 mg, 0.017 mmole), cesium carbonate (360 mg, 0.950 mmole), piperazine (215 mg, 2.5 mmole), Pd2(dba)3 (10 mg, 0.010 mmole), and 1.5 mL of DMF. The reaction vessel was purged with nitrogen and heated to reflux. After three hours, the reaction mixture was cooled to room temperature, and the solvent was removed under reduced pressure. The residue was purified by thin-layer chromatography on a 500 micron silica gel preparative plate with an elution mixture of chloroform methanol water ammonia (80 20 2 0.2) to give 101 mg of 15a as an off-white solid in 58% yield and, separately, 29 mg of 17 as a light brown solid in 22% yield. Using this procedure, the yield of 15a... [Pg.419]

Lee H-B, Peart, T.E. and Svoboda, M.L. (2007) Determination of ofloxacin, norfloxacin, and ciprofloxacin in sewage by selective solid-phase extraction, liquid chromatography with fluorescence detection, and liquid chromatography-tandem mass spectrometry. J Chrom A, 1139 (1), 45-52. [Pg.61]

Nilsson-Ehle, I. Assay of ciprofloxacin and norfloxacin in serum and urine by high-performance liquid chromatography. J.Chromatogr., 1987, 416, 207-211... [Pg.356]

Mizuno, A. Uematsu, T. Nakctshima, M. Simultaneous determination of ofloxacin, norfloxacin and ciprofloxacin in human hair by high-performance liquid chromatography and fluorescence detection. J.Chromatogr.B, 1994, 653, 187—193... [Pg.359]

Ohkubo, T. Kudo, M. Sugawara, K. Determination of ofloxacin in human serum by high-performance liquid chromatography with column switching. J.Chromatogn, 1992, 573, 289-293 Budvdri-Barany, Z. Szdsz, G. Takdcs-Novak, K. Hermecz, I. Lore, A. The pH influence on the HPLC-retention of chemotherapeutic fluoroquinolone derivatives. J.Liq.Chromatogn, 1991,14, 3411-3424 [also amifloxacin, ciprofloxacin, lomefloxacin, nalidixic add, norfloxacin, oxolinic add, pefloxacin]... [Pg.1043]

Groeneveld, A.J. Brouwers, J.R. Quantitative determination of ofloxacin, ciprofloxacin, norfloxacin and pefloxacin in serum by high pressure liquid chromatography. Pharm.Weekbl.[Sci]., 1986, 8, 79—84... [Pg.1043]

Schneider, M.J. Donoghue, D.J. Multiresidue analysis of fluoroquinolone antibiotics in chicken tissue using liquid chromatography-fluorescence-multiple mass spectrometry, J.Chromatogr.B, 2002, 780, 83 92. [ciprofloxacin norfloxacin danofloxadn enrofloxacin orbifloxacin sarafloxacin difloxacin LOQ 10 n g]... [Pg.474]

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