Noradrenergic agonists

Sukul NC, Cherian L, Klemm WR. 1988. Alpha noradrenergic agonists promote catalepsy in the mouse. Pharmacol Biochem Behav 31 87-91. 

Svensson, T. H., Bunney, B. S., and Aghajanian, G. K. (1975) Inhibition of both noradrenergic and serotonergic neurons in brain by the alpha-adrenergic agonist, clonidine. Brain Res., 92 291— 306. 

Another widely practiced strategy to treat sexual dysfunction is the addition of pro-noradrenergic or pro-dopaminergic medications such as dopamine agonists or psychostimulants. The addition of bupropion is also believed to be effective but its mechanism of action remains obscure. 

The mechanisms of action of phencyclidine and ketamine are complex (Gorelick Balster, 1995). The drugs are non-competitive antagonists at NMDA receptors, and also bind to associated phencyclidine/sigma opioid receptors. They also have agonist actions at dopamine receptors, complex interactions with both nicotinic and muscarinic acetylcholine receptors and poorly understood interactions with noradrenergic and serotonergic systems. These multiple actions may combine to produce delirium and psychotic reactions. 

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