Opioids sigma receptors

Other effects observed in vitro include opioid sigma receptor binding using the hypericin fraction and GABA receptor binding using the commercial extract. Interleukin-6 production is also reduced in the presence of the extract. 

Sircar R. Nichtenhauser, R. Ieni, J.R. and Zukin, S-R Characterization and autoradiographic visualization of 3H-(+)SKF-10,047 binding in rat and mouse brain Further evidence for sigma opioid/phencyclidine receptors commonality. Submitted for publication. 

Flavonoids Sigma receptor binding PKC inhibitor PTKinase inhibitor IL-6 inhibitor Opioid jL/ and k binding... 

It is thought that dextromethorphan and noscapine act on sigma receptors (centrally and peripherally) rather than at classic opioid receptors (Brown et al. 2004). However, the inhibitory effect of noscapine on the bradykinin B2 receptor (Ebrahimi et al. 2003) and dextromethorphan s activity at NMDA receptors (Brown et al. 2004) may also contribnte to the antitnssive activity of these drugs. Some research has been nndertaken with newer, more efficacious sigma agonists such as SKF-10,047 (Brown et al. 2004), although plenty of opportunities remain for further investigation in this area. 

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