Nolinium bromide

During early 1979, a literature search for new anti-secretory compounds with unknown mechanisms of action had been carried out to identify interesting compounds and to analyze the competitive situation in the anti-ulcer field. New anti-secretory compounds of unknown mechanism of action (Fig. 3.4) appeared in the scientific or patent literature, and included CMN-131 (Science-Union), tiquina-mide (Wyeth-Ayerst), trithiozine (ISF Lab. Biomed. Res.), nolinium bromide (Norwich), and timoprazole (Hassle) [20]. 

Nolinium bromide (351) blocks the entry of K" " in the gastric H+-K+-dependent ATPase, interfering with the enzyme turnover, and is thus potentially useful as an antiulcer agent <87BJ(241)175>. 

Although CE-LINF, using a UV Ar" " laser, has been applied to the analysis of DNA, the majority has been performed by using visible lasers such as Ar" at 488 nm and He-Ne laser at 543.6 nm. These visible lasers are employed to excite DNA labeled covalently with fluorophores, such as modified fluorescein and rhodamine or intercalated DNA complexes. Some intercalating dyes, such as ethidium bromide (EtBr), benzothiazohum-4-qui-nolinium dimer (TOTO-1), benzoxazolium-4-quinolinium... 

---