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Nociceptin/ orphanin FQ peptide

Compound 24 represents a series of potent spiropiperidine GlyT-1 inhibitors that showed significant binding to the p opioid and nociceptin/ orphanin FQ peptide (NOP) receptors [67]. The hydroxy analog 25 demonstrated improved selectivity and N-propyl analog 26 exhibited increased microsomal stability but reduced GlyT-1 potency (EC50 = 450 nM) [68]. [Pg.27]

Moran TD et al. Cellular neurophysiological actions of nociceptin/orphanin FQ. Peptides 2000 21 969-976. [Pg.329]

Ouagazzal AM, Moreau JL, Pauly-Evers M, Jenck F. Impact of environmental housing conditions on the emotional responses of mice deficient for nociceptin/orphanin FQ peptide precursor gene. Behav. Brain Res. 2003 144 111-117. [Pg.2262]

Calo, G., Bigoni, R., Rizzi, A., Guerrini, R., Salvadori, S., Regoli, D. Nociceptin/orphanin FQ receptor ligands, Peptides 2000, 21, 935-947. [Pg.147]

Joseph T, Lee TL, Li C, Siau C, Nishiuchi Y, Kimura T, Tachibana S (2007) Levels of neuropeptides nocistatin, nociceptin/orphanin FQ and their precursor protein in a rat neuropathic pain model. Peptides 28 1433-1440... [Pg.504]

Okuda-Ashitaka E, Ito S (2000) Nocistatin a novel neuropeptide encoded by the gene for the nociceptin/orphanin FQ precursor. Peptides 21 1101-1109 Okuda-Ashitaka E, Minami T, Tachibana S, Yoshihtira Y, Nishiuchi Y, Kimura T, Ito S (1998) Nocistatin, a peptide that blocks nociceptin action in ptiin transmission. Nature 392 286-289... [Pg.515]

Mogil, J.S. and Pasternak, G.W. The molecular and behavioral pharmacology of the orphanin FQ/ nociceptin peptide and receptor family, Phamacol. Rev. 2001, 53, 381-415. [Pg.474]

The endogenous ligands for the opioid receptors are peptides known as the endorphins (endogenous morphine) or opio-peptins. These include the pentapep tides methionine-enkephalin and leucine-enkephalin and a hep tapep tide and octapeptide version of methionine-enkephalin, all derived from preproenkephalin p-endorphin derived from proopiomelanocortin a-and p-dynorphin derived from prodynorphin endomorphin-1 and -2, whose precursor has not been definitively identified and orphanin FQ or nociceptin, derived from OFQ/N precursor protein. These peptides are discussed in more detail in Chapter 34. [Pg.552]

There are several newly discovered peptides that are related to those already discussed above and that appear to have, in varying degrees, a role in neuroimmune function. Nociceptin, or Orphanin FQ, is a 17 amino acid peptide that plays a role in pain sensation as well as other complex CNS functions. The... [Pg.486]

Endomorphin-1 (52) Tyr-Pro-Trp-PheNH2 Endomorphin-2 (53) Tyr-Pro-Phe-PheNH2 Orphanin FQ/nociceptin and related peptides Orphanin FQ/... [Pg.357]

See other pages where Nociceptin/ orphanin FQ peptide is mentioned: [Pg.451]    [Pg.269]    [Pg.451]    [Pg.269]    [Pg.258]    [Pg.468]    [Pg.327]    [Pg.356]    [Pg.467]    [Pg.571]    [Pg.514]    [Pg.784]    [Pg.451]    [Pg.976]    [Pg.247]    [Pg.66]    [Pg.69]    [Pg.165]    [Pg.509]    [Pg.512]    [Pg.264]    [Pg.373]    [Pg.319]    [Pg.301]    [Pg.120]    [Pg.681]    [Pg.475]    [Pg.693]    [Pg.452]    [Pg.513]    [Pg.520]    [Pg.784]    [Pg.3122]    [Pg.208]    [Pg.209]    [Pg.209]    [Pg.332]   


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Nociceptin

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