NMDA-blocking Pharmaceutical Compositions

The present invention relates to pharmaceutical compositions for preventing excitatory amino acids neurotoxicity comprising as active ingredient (3S,4S)-tetrahydrocannabinol (THC) type compounds of general formula (I), as hereunder defined. [Pg.52]

The compositions of the present invention are particularly effective in alleviating and even preventing glutamate neurotoxicity due [Pg.52]

The compositions of the present invention are also effective in the treatment of certain chronic degenerative diseases which are characterized by gradual selective neuronal loss. In this connection, the compositions of the present invention are contemplated as therapeutically effective in the treatment of the Alzheimer s disease. [Pg.53]

The present compositions are of special value in grand mal seizures, global hypoxic ischemic insults, in hypoxia, alone or in combination with blood flow reduction (ischemia) as well as in cases of cardiac arrest and in cases of abrupt occlusion of cerebral arteries (stroke). [Pg.53]

12-dihydro-6-hydroxy-cannabidiol and the use thereof for the production of m s-delta-9-tetrahydrocannabinol [Pg.53]

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