Big Chemical Encyclopedia

Chemical substances, components, reactions, process design ...

Articles Figures Tables About

Nitrous acid hydrogen chloride, reaction with

Aniline 77 was converted into its diazonium salt with nitrous acid and this was followed by reduction with stannous chloride to afford the corresponding arylhydrazine 78. Condensation of 78 with 3-cyanopropanal dimethylacetal 79 gave the arylhydrazone 80. Treatment of 80 with PPE resulted in cyclization to indole 81. The nitrile group was then reduced to the primary amine by catalytic hydrogenation. Reaction of the amine with excess formalin and sodium borohydride resulted in Imitrex (82). [Pg.125]

The behavior of aminopyrazole 88 (R = 4-NO2—C6H4) under these conditions was quite different diazotization using nitrous acid in concentrated hydrochloric acid afforded an alkynylpyrazole diazonium chloride, which did not participate in the Richter reaction, probably due to the electron-withdrawing effect of the nitro group. Instead, after neutralization of the hydrochloric acid with sodium hydrogen... [Pg.66]

Condensation of ethyl acetoacetate with phenyl hydrazine gives the pyrazolone, 58. Methylation by means of methyl iodide affords the prototype of this series, antipyrine (59). Reaction of that compound with nitrous acid gives the product of substitution at the only available position, the nitroso derivative (60) reduction affords another antiinflammatory agent, aminopyrine (61). Reductive alkylation of 61 with acetone in the presence of hydrogen and platinum gives isopyrine (62). Acylation of 61 with the acid chloride from nicotinic acid affords nifenazone (63). Acylation of 61 with 2-chloropropionyl chloride gives the amide, 64 displacement of the halogen with dimethylamine leads to aminopropylon (65). ... [Pg.234]

Hydroxyimino-2-phenylacetonitrile has been prepared from benzyl cyanide by reaction with nitrous acid, with isoamyl nitrite and sodium ethoxide, and with butyl nitrite and hydrogen chloride." ... [Pg.186]


See other pages where Nitrous acid hydrogen chloride, reaction with is mentioned: [Pg.1014]    [Pg.205]    [Pg.28]    [Pg.243]    [Pg.659]    [Pg.401]    [Pg.874]    [Pg.631]    [Pg.22]    [Pg.51]    [Pg.335]    [Pg.302]    [Pg.391]    [Pg.203]    [Pg.205]    [Pg.205]    [Pg.470]    [Pg.669]    [Pg.59]    [Pg.387]    [Pg.149]    [Pg.130]    [Pg.81]    [Pg.109]    [Pg.219]    [Pg.280]    [Pg.288]    [Pg.315]    [Pg.386]    [Pg.460]    [Pg.462]    [Pg.464]    [Pg.465]    [Pg.467]    [Pg.492]    [Pg.499]    [Pg.585]    [Pg.613]    [Pg.614]    [Pg.698]    [Pg.700]    [Pg.817]    [Pg.850]   
See also in sourсe #XX -- [ Pg.275 ]




SEARCH



Acid chlorides, reactions

Acids Nitrous acid

Chloride reaction with acid

Hydrogen chloride acidity

Hydrogen chloride reactions with

Hydrogenation acid chlorides

Hydrogenation reaction with

Nitrous acid

Nitrous acid, reactions

Nitrous reaction

Reaction with hydrogen

Reaction with nitrous acid

With nitrous acid

© 2024 chempedia.info