Nitroglycerin drug

Karim, A. Transdermal absorption a unique opportunity for constant delivery of nitroglycerin. Drug Develop. Ind. Pharm. 1983, 9, 671. 

Letendre PW, Barr C, Wilkens K. Adverse dermatologic reaction to transdermal nitroglycerin. Drug InteU Qin Pharm 1984 18(l) 69-70. 

Ethylene glycol is widely used as an antifreeze. Glycerol is formed as a byproduct in making soaps. It is a viscous, sweet-tasting liquid, used in making drugs, antibiotics, plastics, and explosives (nitroglycerin). 

The nitrates are available in various forms (eg, sublingual, transmucosal, translingual spray, and inhalation). Some adverse reactions are a result of the metiiod of administration. For example, sublingual nitroglycerin may cause a local burning or tingling in the oral cavity. However, die patient must be aware that an absence of this effect does not indicate a decrease in the drug s potency. Contact dermatitis may occur from use of die transdermal delivery system. 

Transdermal patches arc applied to the skin. The drug is mixed with the adhesive for the patch, and so it lies next to in readily absorb many chemicals and so uch as nitroglycerin (for heart disease),... 

The seated position is generally preferred when using nitroglycerin since the drug may cause dizziness. 

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