Nitrogenase overview

These were relatively low-resolution structures, and with refinement some errors in the initial structural assignments have been detected (4-7). Since the structures were first reported the subject has been extensively reviewed in this series (8) and elsewhere 9-15). This review will focus on the structure, biosynthesis, and function of the met-allosulfur clusters found in nitrogenases. This will require a broader overview of some functional aspects, particularly the involvement of MgATP in the enzymic reaction, and also some reference will be made to the extensive literature (9, 15) on biomimetic chemistry that has helped to illuminate possible modes of nitrogenase function, although a detailed review of this chemistry will not be attempted here. This review cannot be fully comprehensive in the space available, but concentrates on recent advances and attempts to describe the current level of our understanding. 

Contents E. I. Solomon, K. W.Penfield, D.E. Wilcox Active Sites in Copper Proteins. An Electronic Structure Overview. -B.A.Averill Fe-S and Mo-Fe-S Clusters as Models for the Active Site of Nitrogenase. - N.D. Chasteen The Biochemistry of Vanadium. -KKustin, G.C. McLeod, T.R. Gilbert,... 

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