Nitrogen discovery solubility

Bhattachar, S.N., Wesley, J.A., and Seadeek, C. 2006. Evaluation of the chemiluminescent nitrogen detector for solubility determinations to support drug discovery. J. Pharm. Biomed. Anal. 41 152. 

Since most compounds in drug discovery have a chromophor and are nitrogen containing up to 70 % of all samples can be taken into account for a measurement. The sample consumption is very low. Poor solubility of an analyte in the used buffer system is major hurdle of the method. If a compound precipitate during the measurement dramatic UV changes are observed. If the compound is not soluble in water at all it will precipitate in the mother plate. Thus no UV change will be observed due to lack of compound. This will lead to false negative results. 

The development of the new field of organometal chemistry during the last two decades has led to the discovery of many unusual organometal complexes which are soluble in organic solvents. The ability of some of these complexes to react with molecular oxygen or with molecular nitrogen imder very mild conditions has been of particular interest because the complexation of these simple but ubiquitous molecules to transition metals constitutes the first step in two of the most... 

The PubChem Dataset A randomly selected subset of 1000 measured solubility values selected from a set of 58,000 values that were experimentally determined using chemilumenescent nitrogen detection (CLND) by the Sanford-Bumham Medical Research histimte and deposited in the PubChem database (AID 1996) [23] This dataset is composed primarily of screening compounds from the NIH Molecular Libraries initiative and can be considered representative of the types of compounds typically found in early stage drug discovery programs. Values in this dataset were reported with a qualifier < to indicate whether the values were below,... 

Discovery of bacterial nitrogen fixation was yet another impressive illustration of the critical dependence of the element s biospheric pathways on microorganisms. Less than a decade before Hellriegel s lecture, a convincing experiment demonstrated the bacterial origins of nitrification, conversion of ammonia to nitrate. This reaction is of great importance for all crops because nitrates are much more soluble than ammonia is, and plant roots can absorb them more readily from solutions in soil. 

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