Nitric oxide direct application

Uses. Since 1947, 70 to 85% of the annual USA production of nitric acid has gone into the production of NH4 nitrate fertilizer, initially in the form of solid prills currently, increasing amounts have been supplied mixed with excess ammonia and/or urea as aqueous nitrogen solution for direct application to the soil. Some 15% is used in explsj (nitrates nitro compds), and about 10% is consumed by the chemical industry. As the red fuming acid or as nitrogen tetroxide, nitric acid is used extensively as the oxidizer in proplnts for rocketry. It is estimated that current USA capacity for nitric acid is in excess of 10 million tons (Refs 30, 34, 36 37)... 

Structure 139 represents a cephalosporin conjugate of SIN-1 13 that has been synthesized and evaluated as a /3-lactamase-dependent, nitric oxide-releasing conjugate with potential application in antibody-directed enzyme prodrug therapy (ADEPT) <2003BML1687>. 

Notably, all commercial nitric acid production methods used today are centred around the oxidation of ammonia. It is therefore appropriate to investigate the chemistry of this process, in the knowledge that it is directly applicable to any of the production... 

The application of FTIR directly to cHnical studies and diagnosis has been very much debated. Methods for in vivo monitoring of glucose have until now been more presented in the patent literature than in the scientific literature. IR spectroscopy methods, however, have been described for the in vivo monitoring of glucose, hemoglobin, urea, albumin, phosphocreatine, and nitric oxide [326]. 

Recently it has been reported that cobinamides can act as co-activators of nitric oxide receptor of soluble guanylyl cyclase by direct binding to the catalytic domain of sGC [338]. This offers new possibilities for its therapeutic applications in augmenting the effect of other sGC-targeting drugs. 

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