Nitric oxide, biological transport

K. Schmidt, B.M. List, P. KJatt, and B. Mayer, Characterization of neuronal amino acid transporters uptake of nitric oxide synthase inhibitors and implication for their biological effects, J. Neurochem.64 (1995) 1469-1475. 

Celada, A., and Pastor-Anglada, M. (2000) Nitric oxide regulates nucleoside transport in activated B lymphocytes. Journal of Leukocyte Biology, 67 (3), 345-349. 

Protein-mediated electron transfer is a device used in a diverse array of biological transformadons. Well-known electron transfer processes include the mitochondrial electron transport system, photosynthesis (Chapter 13), and nitrogen flxadon (Chapter 15). Less well known biochemical reactions in which electron transfer plays a crucial role include nitric oxide synthesis and the cytochrome P450 electron transport systems. Each of these mechanisms is briefly oudined. 

A. Weichsel, J.F. Andersen, D.E. Champagne, F.A. Walker and W.R. Montfort (1998) Nature Structural Biology, vol. 5, p. 304 - Crystal structures of a nitric oxide transport protein from a blood-sucking insect . 

NO in the unbound form has a very short lifetime in the cell but can be stabilized by the formation of complexes, i.e. metal-porphyrin nitrosyls, dinitrosyl-iron complexes and S-nitrosothiols, which are cmisidered to be its biological transporters. Nitric oxide has a very high affinity for iron contained in the active sites of proteins [74]. 

Vanin AF (1998) Dinitrosyl iron complexes and S-nitrosothiols are two possible forms for stabilization and transport of nitric oxide in biological systems. Biochemistry 63 782-793... 

Goodrich LE, Paulat F et al (2010) Electronic structure of heme-nitrosyls and its significance for nitric oxide reactivity, sensing, transport, and toxicity in biological systems. Inorg Chem 49 6293-6316... 

L.E. Goodrich, F. Paulat, V.K.K. Praneeth and N. Lehnert (2010) Inorg. Chem., vol. 49, p. 6293 - Electronic structure of heme-nitrosyls and its significance for nitric oxide reactivity, sensing, transport, and toxicity in biological systems . J.A. McCleverty (2004) Chem. Rev., vol. 104, p. 403 Chemistry of nitric oxide relevant to biology . 

In biological systems, 5-nitrosothiols (RSNO) play key roles as reagents for the storage and transport of nitric oxide However, they are usually unstable due... 

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