Nisoldipine Digoxin

DILTIAZEM, NIFEDIPINE, FELODIPINE, LACIDIPINE, LERCANIDIPINE, NICARDIPINE, NISOLDIPINE DIGOXIN Possible T plasma concentrations of digoxin These calcium channel blockers are thought to -l renal excretion of digoxin Monitor digoxin levels carefully... 

Itraconazole Alfentanil, alprazolam, astemizole, atorvastatin, buspirone, cisapride, cyclosporine, delavirdine, diazepam, digoxin, felodipine, indinavir, loratadine, lovastatin, midazolam, nisoldipine, phenytoin, quinidine, ritonavir, saquinavir, sildenafil, simvastatin, sirolimus, tacrolimus, triazolam, verapamil, warfarin... 

Clinically important, potentially hazardous interactions with amiloride, aminoglycosides, amphotericin B, ampicillin, anisindione, anticoagulants, armodafinil, atorvastatin, azathioprine, azithromycin, bacampicillin, basiliximab, bezafibrate, bosentan, bupropion, carbenicillin, caspofungin, cholestyramine, clarithromycin, cloxacillin, co-trimoxazole, corticosteroids, cyclophosphamide, daclizumab, danazol, dicloxacillin, dicumarol, digoxin, diltiazem, disulfiram, echinacea, erythromycin, ethotoin, etoposide, ezetimibe, flunisolide, fluoxymesterone, fluvastatin, foscarnet, fosphenytoin, gemfibrozil, hemophilus B vaccine, HMG-CoA reductase inhibitors, imatinib, imipenem/cilastatin, influenza vaccines, ketoconazole, lanreotide, lopinavir, lovastatin, mephenytoin, methicillin, methoxsalen, methylphenidate, methylprednisolone, methyltestosterone, mezlocillin, mizolastine, mycophenolate, nafcillin, nisoldipine, NSAIDs, orlistat, oxacillin, penicillins, phellodendron, phenytoin, pravastatin, prednisolone, prednisone, pristinamycin, ranolazine, red rice yeast, rifabutin, rifampin, rifapentine, ritonavir, rosuvastatin, simvastatin, sirolimus, spironolactone, St John s wort, sulfacetamide, sulfadiazine, sulfamethoxazole, sulfisoxazole, sulfonamides, tacrolimus, telithromycin, tenoxicam, testosterone, ticarcillin, tolvaptan, trabectedin, triamterene, troleandomycin, ursodeoxycholic acid, vaccines, vecuronium, warfarin, zofenopril... 

Concurrent use can be valuable. Felodipine, gallopamil, lac-idipine, nicardipine and nisoldipine cause small but normally clinically unimportant increases in digoxin levels, while am-lodipine, isradipine and nimodipine appear not to interact. The situation with nitrendipine is uncertain but it possibly causes only a small rise in digoxin levels. 

In 10 patients with heart failure nisoldipine 20 mg daily increased the plasma trough digoxin levels by about 15%.Nisoldipine 10 mg twice daily caused no changes in the pharmacokinetics or haemodynamic effects of digoxin in 8 healthy subjects. ... 

Kirch W, Stenzel J, Dylewicz P, Hutt HJ, Santos SR, Ohnhaus EE. Influence of nisoldipine cn haemod3mamic effects and pksma levels of digoxin. BrJ Clin Pharmacol (198 22,155-... 

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