Nigro-neostriatal dopaminergic

Pycock, C. Milson, J. Firsay, D. and Marsden, C.D. The effect of manipulation of cholinergic mechanisms on turning behavior in mice with unilateral destruction of the nigro-neostriatal dopaminergic system. Neuropharmacoloav 17 175-183, 1978. 

The dopamine-containing nigro-neostriatal dopaminergic neurons possess receptors for dopamine. These dopamine receptors occur on both the nerve terminals within the neostriatum (pre-synaptic autoreceptors) as well as on the soma and dendrites (soma-dendritic autoreceptors). Stimulation of either category of autoreceptor can regulate the synthesis, turnover and release of dopamine in the neostriatum but by different mechanisms. 

Price MT, Fibiger HC (1975) Discriminated escape learning and response to electric shock after 6-hydroxy-dopamine lesions of the nigro-neostriatal dopaminergic projection. Pharmacol Biochem Behav 5 285-290. 

Dopamine is a catecholamine neurotransmitter in the CNS and at some ganglia in the autonomic nervous system. To date, three main types of receptors have been found D1( D2, and D3. The main dopaminergic systems in the brain are the nigro-neostriatal... 

In this section, I will mention the peptides which have be n implicated as being under dopaminergic control. Substance P was among the first peptides discovered in the nigro-neostriatal axis. This peptide occurs in both interneurons and in neurons projecting to the substantia nigra (74). Several pieces of circumstantial evidence point to a dopaminergic effect upon... 

Walters, J. R., R. H. Roth, and G. K. Aghajanian. Dopaminergic Neurons Similar Biochemical and Histochemical Effects of Gamma-hydroxybutyrate and Acute Lesions of the Nigro-neostriatal Pathway. Journal of Pharmacology and Experimental Therapeutics 186 (1973) 630-639. 

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