Nigro-neostriatal dopaminergic neurons

The dopamine-containing nigro-neostriatal dopaminergic neurons possess receptors for dopamine. These dopamine receptors occur on both the nerve terminals within the neostriatum (pre-synaptic autoreceptors) as well as on the soma and dendrites (soma-dendritic autoreceptors). Stimulation of either category of autoreceptor can regulate the synthesis, turnover and release of dopamine in the neostriatum but by different mechanisms. 

In this section, I will mention the peptides which have be n implicated as being under dopaminergic control. Substance P was among the first peptides discovered in the nigro-neostriatal axis. This peptide occurs in both interneurons and in neurons projecting to the substantia nigra (74). Several pieces of circumstantial evidence point to a dopaminergic effect upon... 

Walters, J. R., R. H. Roth, and G. K. Aghajanian. Dopaminergic Neurons Similar Biochemical and Histochemical Effects of Gamma-hydroxybutyrate and Acute Lesions of the Nigro-neostriatal Pathway. Journal of Pharmacology and Experimental Therapeutics 186 (1973) 630-639. 

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