Nicotinic acid structure

Common Name 2-[3-(trifluoromethyl)anilino] nicotinic acid Structural Formula cr... 

We have also noted some strange behaviour with fluorinated pyridines, for example, 3-fluoro nicotinic acid (Structure 6.19 and Spectrum 6.12). The signal for H= (approx. 8.1 ppm) clearly shows couplings of 9.1, 2.9 and 1.7 Hz. The 9.1 Hz coupling must be from the fluorine as it does not appear anywhere else in the spectrum and its chemical shift distinguishes it from either of the other two protons. 

Chemical Name 2-[[3-(trifluoromethyl)phenyl] amino]-3-pyridinecarboxylic acid Common Name 2-[3-(trifluoromethyl)anilino] nicotinic acid Structural Formula ... 

The structures of pyridine, nicotinic acid, nicotinamide, and nicotine. 

Niacin (Fig. 1) is a collective name for all vitamers having the biological activity associated with nicotinamide (= pyridine-3-carboxamide), including nicotinic acid (= pyridine-3-carboxylic acid) and a variety of pyridine nucleotide structures. 

Nicotinamide and nicotinic acid are both white crystalline substances. Their aqueous solution has a maximal UV absorbance at 263 nm. Both vitamers have the same biological activity as they can be converted into each other. Figure 2 shows the structure of the coenzyme forms NAD+ and NADP+. 

Niacin. Figure 1 Structure of nicotinic acid and nicotinamide. 

FIGURE 10.7 Structural formula of nicotinic acid and nicotinamide. 1 — nicotinic acid, 2 — nicoinamide. 

The demetalating abilities of buffer species depend on both their structures and their acidities. Thus, while pyridine-2-carboxylic (picolinic) acid catalyzes the demetalation even of the rather inert lm, its 3- and 4-isomers (nicotinic and isonicotinic acids) are inactive. The difference is rationalized to result from the ability that only coordinated picolinic acid has to deliver a proton to an amidato nitrogen in an intramolecular manner. The reaction order in picolinic acid equals one for la and two for lm. For lm, inactive pyridine and nicotinic acid speed up the demetalation in the presence of picolinic acid (Fig. 8). 

Nicotine adenine dinucleotide phosphate (NADP+), 24 147 Nicotinic acid, 9 477-478 26 291 alkaloid precursor, 2 78 Ni-Cr alloys, 23 499. See also Nickel-chromium entries NiCrAlY coatings, 13 508 nido designation boranes, 4 184-186 boron hydrides, 4 170, 172-176 Nidrel, molecular formula and structure, 5 129t... 

The kinetics of reaction of DABCO (7.66) and nicotinic acid (7.67 R = COOH) with the aminochlorotriazine dye Cl Reactive Red 3 (7.2) were studied under neutral conditions at temperatures in the range 100-130 °C. Quaternisation by DABCO was much more rapid than by nicotinic acid under these conditions. Neutral exhaust dyeing tests at 130 °C using the bis(aminochlorotriazine) analogue Cl Reactive Red 120 (7.48 X = Cl) with the two catalysts confirmed these trends, in that the degree of fixation was greatly increased by DABCO but nicotinic acid showed no appreciable catalytic effect [60]. This difference may be attributable to steric strain of the C-N+ bond in the quaternised triazine structure by the non-planar DABCO substituent. 

G. N. Wernly-Chung, J. M. Mayer, A. Tsantih-Kakouhdou, B. Testa, Structure-Reactivity Relationships in the Chemical Hydrolysis of Prodrug Esters of Nicotinic Acid , Int. J. Pharm. 1990, 63, 129-134. 

Abstract This presentation is a brief review on the resnlts of our work on iodine interaction with thioamides, selenoamides and amides. The thioamides, benzothia-zole-2-thione (BZT) (1), 6-n-propyl-2-thiouracil (PTU) (2), 5-chloro-2-mercap-tobenzothiazole (CMBZT) (3), N-methyl-benzothiazole-2-thione (NMBZT) (4), benzimidazole-2-thione (BZIM) (5), thiazolidine-2-thione (TZD) (6), 2-mercapto-pyridine (PYSH) (7), 2-mercapto-nicotinic acid (MNA) (8), 2-mercapto-benzoic acid (MBA) (9) and 2-mercapto-pyrimidine (PMT) (10) react with producing three type of complexes of formulae [(HL)IJ(l2) (HL= thioamide and n= 0, 1), [(HL) [I3 ] and [(HL-L)]+[l3 ]. The interaction of seleno-amides, derived from, 6-n-propyl-2-thiouracil (RSelJ) (R= Me- (11), Et- (12), n-Pr- (13) and i-Pr- (14)) with I, have also been studied and produced the complexes [(RSeU)IJ of spoke structure. These complexes are stable in non-polar solvents, but they decompose in polar solvents, producing dimeric diselenide compounds or undertake deselenation. 

Niacin is a generic name for a small family of molecules having niacin biological activity. The most common structures that fall into this category are nicotinic acid and nicotinamide ... 

Although the structures for molecules having niacin activity are simple, the forms in which they act in human biochemistry are not so simple. Nicotinic acid and nicotinamide are precursors for three complex coenzymes in multiple oxida-tion/reduction (redox) reactions nicotinamide mononucleotide, NMN nicotinamide adenine dinucleotide, NAD+ and nicotinamide adenine dinucleotide phosphate, NADP. I shall use NAD+ as representative of the class. NADH is the corresponding reduced form. ... 

The alkaloids are also relevant to drug design. Alkaloids are complex heterocyclic compounds that contain nitrogen and thus have base-like (hence the term alkaloid ) properties they are extremely structurally diverse. Nicotine is one of the simplest alkaloids. Oxidation of nicotine produces nicotinic acid, a vitamin that is incorporated into the important coenzyme nicotinamide adenine dinucleotide, commonly referred to as NAD" (oxidized form). The neurotransmitter serotonin is an alkaloid containing the aromatic indole ring system. 

Marszalt, M. R, Markuszewski, M. J., and Kaliszan, R., Separation of nicotinic acid and its structural isomers using l-ethyl-3-methylimidazolium ionic liquid as a buffer additive by capillary electrophoresis, ]. Pharm. Biomed. Anal., 41, 329-332,2006. 

The lack of structural information means that any suggested structure for GTF must be highly speculative. Mertz has suggested1200 that two trans nicotinic acids are coordinated to chromium as illustrated in (258). The first coordination sphere is completed by the various amino adds involved. There is little evidence to support this and it seems unlikely that the hard chromium(III) centre would bind preferentially to the nitrogen group of nicotinic add the idea of N coordination has attracted support and influenced other workers. One product of the reaction of nicotinic acid and chromium(III) (mole ratio 3 1, pH 3.2) has been said to be... 

FIGURE 13-17 Structures of niacin (nicotinic acid) and its derivative nicotinamide. The biosynthetic precursor of these compounds is tryptophan. In the laboratory, nicotinic acid was first produced by oxidation of the natural product nicotine—thus the name. Both nicotinic acid and nicotinamide cure pellagra, but nicotine (from cigarettes or elsewhere) has no curative activity. 

Chain structures are formed by the complexes with p-aminobenzoic acid (13) and nicotinic acid (14).104... 

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