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Nickel imidazole

The pressure dependence of the reaction of Ni + with NH3 has been studied in greater detail and the pH dependence of the nickel-imidazole reaction has been followed by Letter and Jordan. The complexing of nickel(n) by imidazole is unusual in that the protonated as well as the unprotonated form of the ligand reacts. For most unidentate ammonia- and pyridine-type ligands, protonation removes the only non-bonded electron pair on the ligand and the protonated form is not reactive. However, for imidazole one electron pair is essentially non-bonding even in the protonated form and can be used for complexation (Scheme 1). [Pg.263]

Pyrazotes are very resistant to catalytic reduction, resisting hydrogenation over nickel at 150 °C and 100 atm (66AHC(6)347). Imidazoles are generally resistant to reduction. [Pg.74]

Dehydrogenation of A -imidazolines (294 Z = NR) gives imidazoles, but requires quite high temperatures and a catalyst such as nickel or platinum. Alternatively, hydrogen acceptors such as sulfur or selenium can be used (70AHC(12)103). [Pg.78]

Alkylthio groups are oxidized to sulfoxides by H2O2 and readily by various oxidizing reagents to sulfones, e.g. in the imidazole series. The SR group is replaced by hydrogen with Raney nickel, and dealkylation is possible, e.g. of 3-alkylthio-l,2-dithiolyliums to give... [Pg.103]

Reaction of l,3-bis(phenylmethyl)imidazol-2-ylidene with nickel tetra carbonyl gives [(t (C)-1,3-bis(phenylmethyl)imidazol-2-ylidene)Ni(CO)3] (970M2472). Complexes of composition [Ni(CO)2L2] with imidazol-2-ylidenes are also known (93JOM(459)177). Another species to be mentioned in this respect is bis(l,3-dimesitylimidazol-2-ylidene)nickel(0) (94JA4391). 1,3-Dicyclohexylimidazol-2-yUdene substitutes triphenylphosphine or THF from [NiX LJ (X = Cl, Br L PPhj, THF) to yield the stable nickel(II) complexes 69 (X = C1, Br R = Cy) (97OM2209). Another preparation of nickel(II) derivatives is the interaction of... [Pg.135]

Co-condensation reaction of the vapors of l,3-di-rcrt-butylimidazol-2-ylidene and nickel, palladium, or platinum gives the coordinatively unsaturated 14-electron sandwiches [L M] (M=Ni, Pd, Pt) of the carbene type (990M3228). Palladium(O) carbene complexes can also be prepared by the direct interaction of l,3-R2-imidazol-2-ylidenes (R=/-Pr, r-Bu, Cy, Mes) (L) with the palladium(O) compound [Pd(P(o-Tol)3)2] (OOJOM(595)186), and the product at the first stage is [(L)PdP(o-Tol)3l, and then in excess free carbene [PdL ]. [Pg.136]

Ferric ion was immobilized on a Chelating Sepharose Fast Flow column preparatory to the separation of seven enkephalin-related phosphopep-tides.17 Non-phosphorylated peptides flowed through the column, and the bound fraction contained the product. The capacity of the column was found to be 23 pmol/mL by frontal elution analysis. Cupric ion was immobilized on Chelating Superose for the isolation of bovine serum albumin.18 Cupric ion was immobilized on a Pharmacia HiTrap column for the separation of Protein C from prothrombin, a separation that was used to model the subsequent apparently successful separation of Factor IX from prothrombin Factor IX activity of the eluate was, however, not checked.19 Imidazole was used as the displacement agent to recover p-galactosidase from unclarified homogenates injected onto a nickel-loaded IMAC column.20 Pretreatment with nucleases and cleaning in place between injections were required procedures. A sixfold purification factor was observed. [Pg.132]

Reduction of both nickel porphyrins and thiaporphyrins to Ni1 species has been studied by EPR and 2H NMR spectroscopy.179, 2 58 The Ni1 complex of 5,10,15,20-tetraphenyl-21-thiaporphyrin has been isolated and characterized. Reaction of this complex with sulfur dioxide produced a paramagnetic five-coordinated Ni1 S02 adduct, while reaction with nitrogenous base ligands (amines, pyridines, imidazoles) yielded five- and six-coordinate complexes. In addition, the crystal structure of Ni1 diphenyldi-p-tolyl-21-thiaporphyrin has been determined. The coordination geometry about the nickel center is essentially square planar with extremely short Ni—N and Ni—S bonds (Ni—N = 2.015(2) A, 2.014(12) A, and 1.910(14) A and Ni—S = 2.143(6) A).2359... [Pg.488]

Butenolide 231 was obtained by a procedure that did not involve a pyrolytic step (237). Thus, the 5-trityl ether 223c was converted into the thioxocar-bonate 230 upon treatment with A,A -thiocarbonylbis(imidazole). Raney nickel effected the conversion of 230 into 231. [Pg.183]

Nickel(III) peptide complexes have a tetragonally-distorted octahedral geometry as shown by electron spin resonance studies (19) and by reaction entropies for the Ni(III,II) redox couple (17). Axial substitutions for Ni(III)-peptide complexes are very fast with formation rate constants for imidazole greater... [Pg.14]

Figure 3 Biosynthesis and purification of 90-kD elastin analogue analyzed by denaturing polyacrylamide gel electrophoresis (10-15% gradient, visualized by silver staining). Lanes 1-7 time course of target protein expression at 0, 30, 60, 90, 120, 150, and 180 minutes after induction. Lane 9 soluble lysate of induced E. coli expression strain BLR(DE3)pRAMl. Lanes 10-13 protein fractions obtained from immobilized metal affinity chromatography of the lysate on nickel-NTA agarose (imidazole gradient elution). Lanes 8,14 protein molecular weight standards of 50, 75, 100, and 150 kD. Figure 3 Biosynthesis and purification of 90-kD elastin analogue analyzed by denaturing polyacrylamide gel electrophoresis (10-15% gradient, visualized by silver staining). Lanes 1-7 time course of target protein expression at 0, 30, 60, 90, 120, 150, and 180 minutes after induction. Lane 9 soluble lysate of induced E. coli expression strain BLR(DE3)pRAMl. Lanes 10-13 protein fractions obtained from immobilized metal affinity chromatography of the lysate on nickel-NTA agarose (imidazole gradient elution). Lanes 8,14 protein molecular weight standards of 50, 75, 100, and 150 kD.
Nickel, NF (cf ) 4, square planar Y-Thiolate, thioether, N-imidazole, polypyrrole Hydrogenases, hydrolases... [Pg.6]

A variation of the thermal elimination of an alcohol from the neutral 2-alkoxy-1,2-dihydro-l//-imidazole is the preformation of a chelate vic-bisamine complex which is subsequently attacked by an ort/io-ester to form the desired NHC complex. This principle has been shown with nickel and platinum [Eq. [Pg.29]

Ni" forms square-planar bis-complexes with the amidate anions of L-Val, L-Phe, and L-Pro. The structure of bis(Gly)-bis(imidazole)nickel(ii) has been reported and the configuration around the metal atom is cis-O(carboxyl), cis-N(amine), cis-N(imidazole). Tetra- and penta-peptide complexes of nickel(ii) consume oxygen in neutral solutions as the metal ion catalyses peptide oxidation to give a number of products, including amides of amino-acids and peptides, oxo-acids, and C02- ... [Pg.309]

Imidazole was converted by hydrogenation over platinum oxide in acetic anhydride to 1,3-diacetylimidazolidine in 80% yield, and benzimidazole similarly to 1,3-diacetylbenzimidazoline in 86% yield [480. While benzimidazole is very resistant to hydrogenation over platinum at 100° and over nickel at 200° and under high pressure, 2-alkyl- or 2-aryl-substituted imidazoles are reduced in the benzene ring rather easily. 2-Methylbenzimidazole was hydrogenated over platinum oxide in acetic acid at 80-90° to 2-methyl-... [Pg.60]

Some of the ring expansion reactions discussed in Section 2.03.3.3.1 can be extended to five-membered heterocycles containing two or more heteroatoms. Reaction of imidazoles and pyrazoles with dichlorocarbene, for example, gives chloropyrimidines together with small amounts of chloro-pyrazines or -pyridazines, and oxidative ring expansion of 1-aminopyrazole with nickel peroxide gives 1,2,3-triazine (this, in fact, constitutes the only known synthesis of the unsubstituted triazine). There are, however, a number of interesting and useful transformations which are unique to five-membered polyheteroatom systems. [Pg.92]

An N-heterocyclic carbene ligand, formed from l,3-bis-(2,4,6-trimethylphenyl)-3//-imidazol-l-ium chloride and cesium carbonate, with dipalladium tris(dibenzylideneacetone) gave excellent yields (93-96% yields) in the Suzuki coupling of 2-chloropurines and arylboronic acids in anhydrous dioxane <2001TL8751>. The combination of an imidazolium-carbene and nickel(O) bis(cyclooctadiene) formed a catalyst capable of insertion into the C-F bond of 6-fluoropurine nucleosides (Scheme 35) <20050L1149>. [Pg.569]

Durch katalytische Hydrierung mit Raney-Nickel in Ethanol bei 100 bar/100o lassen sich 1,2-disubstituierte 4- oder 5-Chlor-imidazole497 zu 1,2-disubstituierten Imidazolen und mit Palladium auf Aktivkohle in Eisessig 4-Acetylamino-l-benzyl-2-brom-imidazol498 zu 4-Acetyl-amino- 1-benzyl-imidazol enthalogenieren. [Pg.104]


See other pages where Nickel imidazole is mentioned: [Pg.155]    [Pg.155]    [Pg.136]    [Pg.197]    [Pg.163]    [Pg.173]    [Pg.154]    [Pg.393]    [Pg.182]    [Pg.192]    [Pg.9]    [Pg.284]    [Pg.298]    [Pg.375]    [Pg.410]    [Pg.251]    [Pg.61]    [Pg.31]    [Pg.175]    [Pg.211]    [Pg.211]    [Pg.7]    [Pg.22]    [Pg.249]    [Pg.1246]    [Pg.1511]    [Pg.373]    [Pg.82]    [Pg.113]    [Pg.142]    [Pg.561]    [Pg.88]    [Pg.90]   
See also in sourсe #XX -- [ Pg.49 ]




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1.3- Bis imidazol-2-ylidene formation of nickel complexes

Imidazol 2, 3 Raney-Nickel

Nickel complexes imidazole

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