Niamide

With most psychedelics, their activity can probably be considerably enhanced by prior (or possibly concomitant) use of a monoamine oxidase inhibitor (e.g., isocarboxazid (Marplan), nialamide (Niamid), phenelzine (Nardil), and tranylcypromine (Parnate)). Some compounds (e.g., DMT) which have no oral activity, can probably become orally active. These compounds are often prescribed as antidepressants, but it is not a good idea to use them frequently or in large doses. For antidotes to the hallucinogens see Amer. J. Hosp. Pharm. 30,80(1973). 

The most commonly used MAO inhibitors include hydrazines, such as iproniazid, Marsilid, Marplan, Niamid, Nardil, Catron also nonhydrazines such as propargylamines, cyclopropylamines, aminopyrazine derivatives, indolealkylamines, and carbolines. MAO-inhibiting materials discussed in this book include yohimbine various tryptamines, especially 5-MeO-DMT and the alpha-methyltryptamines and the various harmala alkaloids. The latter are especially potent inhibitors, but, like yohimibine and the tryptamines, are short-lasting in action (30 minutes to several hours). Some of the commercial MAO inhibitors listed above are effective for several days to several weeks. 

F Niamide (Pfizer) wfm GB Niamid (Pfizer) wfm J Niamid (Taito Pfizer)... 

Proprietary Name. Niamid(e) 2 -(2-Benzylcarbamoylethyl)isonicotinohydrazide Ci,Hi8N402 = 298.3 CAS—51-12-7... 

NIAMIDE NICAMIDE NICAMINA NICAMINDON NICASIRD NICOBION NICOFORT... 

Monoamine oxidase inhibitors (MAOl) o Nialamide (Niamide) N -(2-BenzylcarbamoyT ethyl)isonicotinohydrazide o Tranylcypromine (Parnate) (+ )-fra s-2-Phe-nylcyclopropylamine sulfate (2 1) o Iproniazid (Marsilid) 2 -lsopropylisonicotino-hydrazide... 

In various animal tests, this drug had 3 to 12 times the MAO-inhibitory potency of iproniazid (89). As a clinical antidepressant (Niamid) the drug is somewhat less effective than iproniazid however, it is devoid of the hepato-toxic properties of the latter agent. 

The pyrrole nucleus is the characteristic structural motif of numerous natural (stor-niamide A, lamellarin P, marinopyrrole B) and synthetic products [24], Many poly-functionalized pyrroles are known to display interesting biological activities [25], In addition, pyrroles were observed to inhibit cytokine-mediated diseases and were also found to have some apphcations in materials chemistry [26], The growing importance and wide usefiilness of polysubstituted pyrroles have kept in focus the search for new methods for the efficient synthesis of these heterocycles. 

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