Hyperuricemia niacin

Niacin 50 to 750 mg tabs or caps, i m med i ate- re I ease 250 to 750 mg sustained-release 1 -5 g/day in three or more divided doses 1-2 g/day (never exceed 2 g/day due to increased risk of hepatotoxicity) hyperuricemia. 

Some drugs can cause hyperuricemia and gout, such as thiazide diuretics, niacin, pyrazinamide, cyclosporine, and occasionally, low-dose aspirin. 

Some drugs can cause hyperuricemia and gout, such as thiazide diuretics, niacin, pyrazinamide, cyclosporine, and occasionally, low-dose aspirin. In most cases, these drugs block uric acid secretion in the kidney. Long-term consequences of gout and hyperuricemia include joint destruction, tophi, and nephrolithiasis. 

The major adverse effect of niacin treatment is intense cutaneous flushing (vasodilation), which manifests as an uncomfortable burning sensation and itchiness of the face and upper body, thereby limiting patient compliance to therapy [13]. Moreover, a short half-life, dyspepsia, hyperuricemia, and modest hyperglycemia were also reported [14-16]. 

Potentially important laboratory abnormalities occurring with niacin therapy include elevated liver function tests, hyperuricemia, and hyperglycemia. Niacin-associated hepatitis is more common with sustained-release preparations, and their use should be restricted to patients intolerant of regular-release products. Niacin is contraindicated in patients with active liver disease, and it may exacerbate preexisting gout and diabetes. 

Nicotinic acid (niacin) Yes Reduces LDL Reduces VLDL Raises HDL IV Ik with fibrates severe IV with fibrates Cutaneous flush, GI distress, liver dysfunction, hyperglycemia, hyperuricemia... 

Chronic megadoses of niacin may be associated with hyperglycemia, hyperuricemia, cardiac arrhythmias, hepatotoxicity, cystoid maculopathy, myopathy, peptic ulcers, and hyperkeratotic pigmented skin lesions. These problems may occur with doses exceeding 3gday. ... 

Niacin can exacerbate both hyperuricemia and glucose intolerance. The answer is (D). 

Efficacy and safety studies with ER niacin have shown benefit, albeit with some safety concerns that were reported many years ago with nicotinic acid, such as small increased risks of hyperglycemia and hyperuricemia. 

---