Next Step products

In the next step, product formation takes place by reductive elimination and the catalytic cycle is completed. This mechanism is commonly referred to as the Chalk-Harrod mechanism. 

In the next step the —OOH group of PGG2 is reduced to an alcohol function Again prostaglandin endoperoxide synthase is the enzyme responsible The product of this step IS called PGH2... 

The next step in increasing oyster culture intensity might involve hatchery production and settling of spat on cultch. Once again, the cultch would be later distributed over a bed leased or owned by the oyster culturist (Eig. 1). Control of predators such as starfish and oyster drills could easily be a part of culture at all levels. 

In pusher furnaces, the product (work load) is pushed through the furnace in steps by a hydrauhc or electromechanical mechanism that pushes each load into the furnace, thus pushing all work in the furnace ahead one work space. The walking-beam furnace lifts the work load on a walking beam, advances the load a step, and returns the work to the hearth. The walking beam then returns to its original position (under the hearth) in preparation for the next step. 

Separation method selection is governed by a two-tier set of rules for selecting among potential operations. The first tier involves the selection between strategic and opportunistic operations. Strategic separations are favored, as these are known to be required in the flow sheet at some point, as are separations which directly reach a desired product composition. The rules in the first tier state that once all the potential opportunistic and strategic operations have been identified for the current stream, the next step is to determine the order in which these operations should be tried. The foUowing... 

Although the submitters report that this crude product is suitable for use in the next step of this preparation, the checkers found that once when using the crude product the subsequent reaction did not go to completion unless an extra quantity of the diamine base was added. This suggests that some potentially acidic impurity such as butyl chloroformate may be present in the crude product and could interfere with the subsequent reaction. The checkers therefore recommend that the product be purified before use in the next step of this preparation,... 

The cream-colored solid is separated at once by filtration and washed thoroughly with water to remove excess bromine water and acids. It is used in the next step without drying. The melting range of the crude product is usually 170-172°. 

The product can be recrystallized readily from dimethyl-formamide to give yellow leaflets, m.p. 290-293°. However, it is pure enough to be used in the next step. This synthesis has also been applied to the preparation of l,4-bis-[4-( -tolyl)buta-dienyljbenzene (100%), l,4-bis-[4-(3-nitrophenyl)butadienyl]-benzene (56%), and l,4-bis-(3-methyl-4-phenylbutadienyl)ben-zene (87%). 

The product is very slightly soluble in most solvents. It was used satisfactorily in the next step without further purification. Melting with sublimation occurs between 285° and 300°, depending on the rate of heating. 

The records of all tests, inspections, analyses, and demonstrations should be generated which demonstrate that the process is safe, meets environment legislation, is reliable, stable, capable, and maintainable and produces products that meet engineering standards. The next step is product approval. 

Hydroxy-B-homo-5a-cholestan-7-one acetate (54b) A solution of 3/3-hydroxy-5a-cholestan-7-one acetate (51b 5 g mp 146-148°) in dioxane-ethanol (100 ml, 1 1) is placed in a 250 ml three-necked flask equipped with a mechanical stirrer and thermometer and is cooled to 0° (iee-salt bath). Powdered potassium cyanide (7.3 g) is added portionwise with stirring. Acetic acid (8 ml) is then added dropwise with constant stirring over 30 min. The resultant mixture is stirred for 1 hr at 0° C and for an additional 2 hr at room temperature. It is then poured into ice water (200 g ice, 100 ml water) and after standing for 1 hr the precipitate is collected by filtration. The product is dissolved in ether (100 ml), the ether solution is washed with 5% sodium bicarbonate, water and dried over anhydrous sodium sulfate. The filtrate is evaporated at reduced pressure and the solid residue (5.1 g) is crystallized from ethyl acetate (30 ml) to yield 2.8 g of cyanohydrin (52b) mp 160-164° repeated crystallization from the same solvent gives a product mp 164-167°. An alternative method of isolation of the cyanohydrin is used when 100 g or larger quantities are worked up. The reaction mixture is poured directly into a mixture of ice water and sodium bicarbonate, the precipitate (mp 155-156°) is washed well with water, dried and used directly for the next step. 

The mechanism of the cycloaddition reaction of benzaldehyde 2a with Danishefsky s diene 3a catalyzed by aluminum complexes has been investigated theoretically using semi-empirical calculations [14]. It was found that the reaction proceeds as a step-wise cycloaddition reaction with the first step being a nucleophilic-like attack of Danishefsky s diene 2a on the coordinated carbonyl compound leading to an aldol-like intermediate which is stabilized by interaction of the cation with the oxygen atom of the Lewis acid. The next step is the ring-closure step, giving the cycloaddition product. 

The next step is the nucleophilic addition of the enolate anion 5 to the carbonyl group of another, non-enolized, aldehyde molecule 2. The product which is obtained after workup is a /3-hydroxy aldehyde or ketone 3 ... 

To a solution of vanillin in toluene is added nitroethane, butylamine and glacial acetic acid. The mixture is refluxed and the water of reaction is steadily azeotropically removed by distillation. After the theoretical amount of water is distilled out, distillation Is continued to remove excess reactants. The last trace of excess reactants is then removed at room temperature under a vacuum. The product is then triturated with a hydrocarbon solvent such as Skellysolve B and is thus obtained in a crystalline state. In general, however, it is preferred to dissolve the residue directly In toluene for use in the next step, without isolating the 1-(2-nitropropen-1-y I )-4-hydroxy-3-methoxy benzene. 

The aqueous phase was discarded and the combined ethereal phases were washed with water, dried over sodium sulfate, filtered and distilled to dryness, to obtain 20.240 grams of 3-me-thoxy-17o-methyl-19-nor-A - " hpregnadiene-20-ol, which product was utilized as such for the next step. The compound occurred in the form of an amorphous product which was soluble in alcohol, ether, benzene and acetone and insoluble in water. 

A mixture of 1.38 grams of the above compound and 15 cc of dioxane was treated with 1.9 cc of a 0.5 N aqueous solution of perchloric acid and 600 mg of N-bromoacetamide, adding the latter in the dark, in three portions, in the course of half an hour and under continuous stirring. It was then stirred for a further 1% hours in the dark, then the excess of reagent was decomposed by the addition of aqueous sodium bisulfite solution and ice water was added the product was extracted with methylene chloride, washed with water, dried over anhydrous sodium sulfate and the solvent was evaporated under reduced pressure, thus giving a yellow oil consisting of the 16,21-diacetate of 6a-fluoro-9a-bromo-16o-hydroxy-hydrocortisone which was used for the next step without further purification. 

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