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The order of procedures that result in the publication of an EHC monograph is shown in the flow chart on the next page. A designated staff member of IPCS, responsible for the scientific quality of the document, serves as Responsible Officer (RO). The IPCS Editor is responsible for layout and language. The first draft, prepared by consultants or, more usually, staff from an IPCS Participating Institution, is based initially on data provided from the International Register of Potentially Toxic Chemicals and from reference databases such as Medline and Toxline. 

Undesirable Effects Masculinization with prolonged use, otherwise minimal toxicity. Undesirable effects of oral contraceptives described on next page. 

Figure 8. (see next page) Proposed mechanisms of the unexpected biological activity and reduced nonspecific toxicity associated with the combination of HPMA copolymer doxorubicin and mesochlorin Cj in the treatment of ovarian cancer. 

Fluorine, found at the top of Group 17, is the most reactive of all the non-metallic elements and is a powerful oxidising agent. The next element in Group 17 is chlorine, also a toxic gas, but its compounds, such as trichlorophenol, are important disinfectants. Compounds of carbon, fluorine and chlorine are known as CFCs and have been responsible for most of the damage to the Earth s ozone layer. You can read more about uses of the halogens and their compounds on page... 

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