Nevirapine Tenofovir

Lopinavir Delavirdine, indinavir, ritonavir, darunavir Fosamprenavir, efavirenz, nelfinavir, nevirapine, tenofovir... 

Cardiovascular A 57-year-old man with HIV infection taking abacavir, nevirapine, tenofovir, voriconazole, and methadone developed new-onset seizures [69 ]. An electrocardiogram showed sinus bradycardia and a prolonged QT interval of 690 msec. He had several episodes of torsade de pointes and ventricular tachycardia, which resolved spontaneously. They were accompanied by altered cognition and... 

Zidovudine Didanosine Stavudine Lamivudine Abacavir Tenofovir Emtricitabine Nevirapine Efavirenz TMC125 Saquinavir Indinavir Lopinavir Fosamprenavir Atazanavir Tipranavir Darunavir Raltegravir Elvitegravir Enluvirtide Maraviroc Vicriviroc Bevirimat... 

Tenofovir + Emtricitabine Zidovudine + Lamivudine Abacavir + Lamivudine Efavirenz or Nevirapine Lopinavir/r or Atazanavir/r or Eosamprenavir/r or Saquinavir/r... 

Therapies not recommended for initial treatment due to poor potency or significant toxicity include delavirdine, nevirapine in patients with moderate to high CD4+ T-cell counts, indinavir or saquinavir used without ritonavir ( unboosted ), ritonavir used without another protease inhibitor, and tenofovir plus didanosine with an NNRTI. 

TC, lamivudine ABC, abacavir APV, amprenavir AST, aspartate aminotransferase ALT, alanine aminotransferase ATV, atazanavir CBC, complete blood cell count D/C, discontinue ddl, didano-sine d4T, stavudine EFV, efavirenz FTC, emtricitabine P1BV, hepatitis B virus F1CV, hepatitis C vims HIV, human immunodeficiency virus IDV, indinavir IV, intravenous LFT, liver function tests LPV/r, lopinavir + ritonavir NNRTI, nonnucleoside reverse transcriptase inhibitor NRTI, nucleoside reverse transcriptase inhibitor NVP, nevirapine PI, protease inhibitor PT, prothrombin time T.bili, total bilirubin TDF, tenofovir disoproxiI fumarate TPV, tipranavir ULN, upper limit of normal ZDV, zidovudine. 

Drugs that may affect atazanavir include the following antacids and buffered medications, clarithromycin, didanosine (buffered formulation only), efavirenz, H2-receptor antagonists, indinavir, itraconazole, ketoconazole, nevirapine, proton pump inhibitors, rifampin, ritonavir, St. John s wort, tenofovir, voriconazole. 

TC Lamivudine ABC Abacavir d4T Stavudine ddC Zalcitabine ddl Didanosine TDF Tenofovir ZDV Zidovudine, also abbreviated as AZT FTC Emtricitabine NVP Nevirapine DLV Delavirdine EFV Efavirenz RTV, r Ritonavir Pl/r Ritonavir boosted protease inhibitor SQV Saquinavir IDV Indinavir LPV Lopinavir NEV Nelfinavir APV Amprenavir ATV Atazanavir DRV Darunavir... 

Etravirine Delavirdine, efavirenz, lopinavir/ritonavir, nevirapine, ritonavir, tipranavir Darunavir, saquinavir, tenofovir... 

Saquinavir Atazanavir, delavirdine, indinavir, lopinavir, nelfinavir, tenofovir Efavirenz, nevirapine, tipranavir... 

Lamivudine -I- Stavudine Lamivudine -I- Zidovudine Lamivudine + Stavudine + Efavirenz Lamivudine -I- Stavudine + Nevirapine Lamivudine -I- Zidovudine + Efavirenz Lamivudine -I- Zidovudine + Nevirapine Lamivudine -I- Zidovudine + Abacavir Tenofovir -I- Emtricitabine... 

ABBREVIATIONS EFV, efavirenz 3TC, lamivudine AZT, zidovudine TDF, tenofovir disoproxil fumarate d4T, stavudine LPV/r, lopinavir/ritonavir coformulation FTC, emtricitabine NVP, nevirapine ddl, didanosine ATV, atazanavir fosAPV, fosamprenavir RTV, ritonavir IDV, indinavir NFV, nelfinavir SQV, saquinavir. 

No clinically significant interaction appears to occur between adefovir and co-trimoxazole, didanosine, delavirdine, efavirenz, ibuprofen, indinavir, lamivudine, nelfinavir, nevirapine, paracetamol, tenofovir, or zidovudine. Adefovir possibly reduces saquinavir levels. 

In 8 patients taking nevirapine, lamivudine and tenofovir the AUC of a single 300-mg dose of maraviroc was unchanged and its maximum plasma level was about 50% higher, when compared with HIV-positive subjects taking maraviroc alone. ... 

No pharmacokinetic interaction appears to occur between tenofovir and efavirenz or nevirapine. Some ciinicai data have shown a high rate of treatment faiiure when tenofovir is given with enteric-coated didanosine and either efavirenz or nevirapine. 

In a pharmacokinetic study, there was no interaction between efavirenz 600 mg daily and tenofovir disoproxil fumarate 300 mg daily.Similarly, in a retrospective analysis, plasma levels of nevirapine 200 mg twice daily or 400 mg once daily did not differ between patients taking tenofovir disoproxil fumarate 300 mg once daily and those not. Also, efavirenz plasma levels did not differ between patients taking tenofovir and patients not taking tenofovir. It appeared that neither nevirapine nor efavirenz altered tenofovir levels. ... 

Droste JA, Kearney BP, Hekster YA, Burger DM. Assesanent of dn -dnig interactions between tenofovir disoproxil fumarate and the ncfinucleoside reverse transcriptase inhibitors nevirapine and efavirenz in HIV-infected patients. J Acquir Immune Defic Symb- (2006) 41,37-... 

Furthermore, a once daily combination of tenofovir disoproxil fumarate 300 mg, enteric-coated didanosine 250 mg and lamivudine 300 mg was unexpectedly associated with a high rate of treatment failure (early viro-logical non-response) in a clinical study in treatment-naive patients. Similarly, other studies have shown a high rate of treatment failure with a once daily combination of tenofovir disoproxil fumarate 300 mg, enteric-coated didanosine 250 mg and either efavirenz or nevirapine in treatment-naive patients with high baseline viral loads and low CD4 counts. A poor immune response (lack of increase in CD4 cell counts) has also been seen with full-dose didanosine plus tenofovir regimens in treatment-experienced patients. ... 

Hodder SL. Re Important new clinical data. Potential early virolc ic failure associated with the combination antiretroviral regimen of tenofovir disc roxil fumarate, didanosine, and either efavirenz or nevirapine in BTV treatment-naive patients with high baseline viral loads. Bristol-Myers Squibb Company, November 2004. Available at http //www.fda.gov/oashi/aids/l]kserv/bms.jx]f (accessed 21/08/07). 

Emtricitabine, Lamivudine, Stavudine, Tenofovir, Zalcitabine (production discontinued), and Zidovudine. Non-nucleoside Reverse Transcriptase Inhibitors include Delavirdine, Efavirenz, and Nevirapine. 

Cardiovascular A previously healthy young man had several episodes of syneope while taking tenofovir, emtricitabine, and nevirapine for primary HTV-l infection. The s)mip-toms resolved after withdrawal of antiretroviral therapy [76 ]. 

Phanuphak N, Ananworanich J, Teeratakulpisarn N, Jadwattanakul T, Kerr SJ, Chomchey N, et al. A 72-week randomized study of the safety and efficacy of a stavudine to zidovudine switch at 24 weeks compared to zidovudine or tenofovir disoproxil fumarate when given with lamivudine and nevirapine. Antivir Ther 2012 17(8) 1521-31. 

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