Nevirapine observational studies

Observational studies In 2190 adults taking stavudine and nevirapine (median followup 1.5 years), stavudine had to be replaced in 175 (8.0%) because of neuropathy, in 69 (3.1%) because of lactic acidosis and in 157 (7.2%) because of Upoatrophy significant susceptibility factors associated with lactic acidosis and late neuropathy included a higher baseline body weight and older age advanced HIV disease increased the risk of neuropathy [661. 

The fact that 12-hydroxylation of nevirapine is required in order to induce a rash appears to be in conflict with the observation that peripheral mononuclear blood cells from patients with a history of nevirapine-induced hypersensitivity reactions were activated by the parent drug in the absence of a metabolizing system. When the response of cells from the cervical lymph nodes of sensitized rats was studied, they also responded to nevirapine by producing IFN-y analogous to the human study, but... 

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