Nevirapine Hormonal contraceptives

NEVIRAPINE OESTROGENS -ETHINYLESTRADIOL Marked si contraceptive effect with nevirapine Induction of metabolism of oestrogens Avoid co-administration, recommend alternative non-hormonal contraceptives - barrier methods are necessary to prevent transmission of infection... 

It is likely that nevirapine induces the metabolism of the components of the oral contraceptive by cytochrome P450 isoenzymes. Although it is not known whether these modest reductions in levels would reduce the anti-ovulatory efficacy of the combined oral contraceptive, it would be prudent to assume they could. The manufacturers recommend that combined oral contraceptives and other hormonal methods of birth control should not be used as the sole method of contraception in women taking nevirapine. They suggest that a barrier method (e.g. condoms) should also be used, and note that this is also advisable to reduce the risk of HTV transmission. The Faculty of Family Planning and Reproductive Health Care (FFPRHC) Clinical Effectiveness Unit notes that nevirapine can induce liver enzymes and may reduce the levels of ethinylestradiol and progestogens. They therefore recommend that their guidance on hormonal contraceptives and liver enzyme inducers is followed, see Hormonal contraceptives + Antiepileptics Barbiturates or Phenytoin , p.985 for fiir-ther detail. 

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See also in sourсe #XX -- [ ]

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