Neurotoxicity testing developmental

Ton C, Lin Y, Willett C (2006) Zebrafish as a model for developmental neurotoxicity testing. Birth Defects Res A Clin Mol Teratol 76 553-567... [Pg.411]

EPA Toxic Substances Control Act Manufacturers and processors of the C, aromatic hydrocarbon fraction must test this fraction for the following neurotoxicity, mutagenicity, developmental toxicity, reproductive effects, and oncogenicity Yes EPA 1991a (40 CFR 799.2175) EPA 1987c... [Pg.160]

The developmental neurotoxicity test (OECD TG 426 Draft, US-EPA OPPTS 870.6300) can be conducted as a separate study, incorporated into a reproductive toxicity study and/or adult neurotoxicity study, or added onto a prenatal developmental toxicity study. [Pg.184]

If peri-postnatal tests, developmental neurotoxicity smdies, or specific male or female fertility studies are available they can be used to identify a substance as being toxic to reproduction. Data from such studies alone cannot be used to identify a substance as being of no concern in relation to reproduction. [Pg.187]

Some of these side effects may be impossible to detect either in vivo or using alternative model systems nevertheless, the availability of models that would be predictive of neurotoxic effect is of great relevance for the risk assessment of existing chemicals and of new molecular entities. In vivo testing guidelines for neurotoxicity and developmental neurotoxicity have been developed, implemented, and validated. Though there is still room for improvements and refinements, these in vivo tests have been shown, so far, to provide reliable indications on the potential neurotoxicity of chemical substances. However, such in vivo tests are time consuming and expensive and require the use of a substantial number of animals. [Pg.148]

Radio NM, Mundy WR. Developmental neurotoxicity testing in vitro Models for assessing chemical effects on neurite outgrowth. Neurotoxicology. 2008 29 361-376. [Pg.150]

Ethanolamines have not been found to be developmental toxins in standard or screening assays nor was diethanolamine found to be neurotoxic in a standard neurotoxicity test following subchronic inhalation exposure up to 400 mg m... [Pg.1079]

Lau K, McLean WG, Williams DP, Howard CV. Synergistic interactions between commonly used food additives in a developmental neurotoxicity test. Toxicol Sci 2006 90(1) 178-87. [Pg.154]

In Vitro Developmental Neurotoxicity Testing Relevant Models and Endpoints... [Pg.127]

Crofton KM, Mundy WR, Shafer TJ (2012) Developmental neurotoxicity testing a path forward. Congenit Anom (Kyoto) 52 140-146... [Pg.141]

Moors M, Rockel TD, Abel J, Cline JE, Gassmann K, Schreiber T, Schuwald J, Weinmann N, Fritsche E (2009) Human neurospheres as three-dimensional cellular systems for developmental neurotoxicity testing. Environ Health Perspect 117 1131-1138... [Pg.142]

Laurenza I, Pallocca G, Mennecozzi M, Scelfo B, Pamies D, Bal-Price A (2013) A human pluripotent carcinoma stem cell-based model for in vitro developmental neurotoxicity testing effects of methylmercury, lead and aluminum evaluated by gene expression studies. Int J Dev Neurosci 31(7) 679-691... [Pg.142]

Lein P, Silbergeld E, Locke P, Goldberg AM (2005) In vitro and other alternative approaches to developmental neurotoxicity testing (DNT). Environ Toxicol Pharmacol 19(3) 735-744... [Pg.368]

Lein P, Locke P, Goldberg A (2007) Meeting report alternatives for developmental neurotoxicity testing. Environ Health Perspect 115(5) 764-768... [Pg.368]

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