Neuroprotective Strategies

Thrombolytics and drugs targeting several injury pathways have shown efficacy in models of hypoxia-ischemia. A number of neuroprotective strategies have been identified in animal models of ischemia, and many... 

By revealing the identity of a spectrum of molecules involved in different cellular functions, such results provide a means for mechanistic speculation and the subsequent development of neuroprotective strategies. Results such as these are now commonly used as a reference for predicting the functions of cells under given conditions and in assigning putative biological process aimotation to unknown genes. 

Stenzel-Poore MP, Stevens SL, Xiong Z, Lessov NS, Harrington GA, et al. 2003. Effect of ischaemic preconditioning on genomic response to cerebral ischaemia similarity to neuroprotective strategies in hibernation and hypoxia-tolerant states. Lancet 362 1028. 

Suchowersky et al. Practice parameter Neuroprotective strategies and alternative therapies for Parkinson disease (an evidence-based review). Report of the Quality Standards Subcommittee of the American Academy of Neurology. 

Rothstein J. D. andKuncl R. W. (1995). Neuroprotective strategies in a model of chronic glutamate-mediated motor neuron toxicity. J. Neurochem. 65 643-651. 

Using Caenorhabditis elegans Models of Neuro-degenerative Disease to Identify Neuroprotective Strategies... 

Comprehensive and up-to-date, Hypothermia and Cerebral Ischemia Mechanisms and Clinical Applications summarizes for clinicians and basic scientists alike all that is known about the use of hypothermia as a neuroprotective strategy in the treatment of today s stroke and TBI patients. 

Grunblatt E, Mandel S, Youdim MB (2000) Neuroprotective strategies in Parkinson s disease using the models of 6-hydroxydopa-mine and MPTP. Ann NY Acad Sci 899 262-273. 

Gelbard HA (1999) Neuroprotective strategies for HIV-l-associated neurologic disease. Ann N Y Acad Sci 890 312-313. 

Neurodegeneration is likely due in part to caspase enzyme driven apoptosis and drugs that inhibit the activation of caspase enzymes are being studied as a potential neuroprotective strategy. 

Figure 4. The classes of ion channel drugs that are effective in neuroprotection strategies.

Alexi T, Borlongan CV, Faull. RLM, Williams CE, Clark RG, Gluckman PD, et al. Neuroprotective strategies for basal ganglia degeneration Parkinson s and Huntington s diseases. Prog Neurobiol 2000 60 409 70. 

Springer, J.E., Kitzman, P.H., 1998. Neuroprotective strategies involving the neurotrophins and their signaling pathways. In Mattson, M.P. (Ed.), Neuroprotective Signal Transduction. Humana Press, Totowa, NJ, pp. 1-21. 

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