Neuromuscular blocking drugs morphine

Fisher MM, Baldo BA. Immunoassays in the diagnosis of anaphylaxis to neuromuscular blocking drugs the value of morphine for the detection of IgE antibodies in allergic subjects. Anaesth Intensive Care 2000 28(2) I67-70. 

Table 7.9 Incidences of positive IgE antibody test for neuromuscular blocking drugs in the sera of a homogeneous group of patents who experienced an anaphylactic reaction during anesthesia. Comparison of the morphine immunoassay with immunoassays for individual drugs ...

Patients skin test positive to Number positive Morphine test Neuromuscular blocking drug (or analog) tesb... 

Interactions. Morphine (also pethidine and possibly other opioids) is potentiated by monoamine oxidase inhibitors. Any central nervous system depressant (including alcohol) will have additive effects. Patients recently exposed to neuromuscular blocking agents (unless this is adequately reversed, e.g. by neostigmine) are particularly at risk from the respiratory depressant effects of morphine. The effect of diuretic drugs may be reduced by release of antidiuretic hormone by morphine. Useful interactions include the potientating effect on pain relief of tricyclic antidepressants and of dexamfetamine. 

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