Neuroleptic malignant syndrome NMS

Other sedative-hypnotic medications, such as barbiturates, may play a useful role in severe withdrawal from this group of drugs. For example, in a case series of GBL withdrawal, use of intravenous pentobarbital in the range of 1-2 mg/kg/hour lowered the total requirement for intravenous lorazepam (Sivilotti et al. 2001). Antipsychotic medications are often used to reduce psychotic agitation. However, because antipsychotic medications lower the seizure threshold and may contribute to loss of central control of temperature leading to hyperthermia or neuroleptic malignant syndrome (NMS), they are not indicated as first-line medications for GHB withdrawal delirium (Dyer and Roth 2001 McDaniel and Miotto 2001 Sharma et al. 2001). If anti-... 

Once neuroleptic malignant syndrome (NMS) develops, signs and symptoms may escalate over 24—72 h and may have a prolonged clinical course... 

Neuroleptic malignant syndrome (NMS) A potentially fatal symptom complex sometimes referred to as NMS has been reported in association with promethazine alone or in combination with antipsychotic drugs. Clinical manifestations of NMS are hyperpyrexia, muscle rigidity, altered mental status, and evidence of autonomic instability (eg, irregular pulse or blood pressure, tachycardia, diaphoresis, cardiac dysrhythmias). 

Neuroleptic malignant syndrome (NMS) NMS is a potentially fatal condition reported in association with antipsychotic drugs and with amoxapine. 

Neuroleptic malignant syndrome (NMS) Sporadic cases of possible NMS have been reported in association with dose reduction or withdrawal of amantadine therapy. Observe patients carefully when the dosage of amantadine is reduced abruptly or discontinued, especially if the patient is receiving neuroleptics. 

Serious reactions such as blood dyscrasias, agranulocytosis, leukocytopenia, thrombocytopenia, cholestatic jaundice, neuroleptic malignant syndrome (NMS), constipation or paralytic ileus, priapism, QT prolongation and torsades de pointes, seizure, systemic lupus erythematosusdike syndrome, and temperature regulation dysfunction (heatstroke or hypothermia) occur rarely. 

Neuroleptic malignant syndrome (NMS) is a rare, medication-induced syndrome that may be due to dopamine receptor blockade in the basal ganglia. An altered level of consciousness, autonomic instability, hyperthermia, and severe muscular rigidity typically... 

Repeated high i.m. doses over several days are inadvisable inasmuch as most patients do not require such aggressive intervention, and this strategy may increase the risk for severe EPS and the neuroleptic malignant syndrome (NMS). Finally, it is preferable to switch patients to oral treatment as quickly as possible to manage the remainder of an acute episode. 

The neuroleptic malignant syndrome (NMS) is an acute disorder of thermoregulation and neuromotor control carrying a mortality rate of about 21 % when untreated. The term neuroleptic malignant syndrome is probably a misnomer, and a better name might be the hypodopaminergic, hyperpyrexia syndrome. ... 

Neuroleptic Malignant Syndrome. Patients taking relatively high doses of the more potent antipsychotics may experience a serious disorder known as neuroleptic malignant syndrome (NMS).48 Symptoms of NMS... 

Monitor for symptoms of neuroleptic malignant syndrome (NMS) increased fever, pulse, and blood pressure, muscle rigidity, increased creatine phosphokinase, and WBC count altered mental status, acute renal failure, varying levels of consciousness pallor diaphoresis, tachycardia, and dysrhythmias. 

Assess for tardive dyskinesia and neuroleptic malignant syndrome (NMS). 

The relationship between ethnicity and neuroleptic malignant syndrome (NMS) is unknown. In case reports and epidemiological studies, the age and sex of patients with NMS have typically been noted, but ethnicity has not. A study in China found that 0.63% of patients in whom treatment with antipsychotic medication was begun developed NMS (Deng et al. 1990), and an Indian study found 0.2% of patients developing the disorder (Singh 1981). These rates are similar to those found in American and European studies. 

Acute toxic syndrome due to increased 5-HT activity (can be confused with neuroleptic malignant syndrome, NMS, see Chapter 3). 

Additionally, ECT is highly effective for mania, catatonic states, and certain cases of schizophrenia. Moreover, it has been reported to ameliorate the motor symptoms of Parkinson s disease and various other movement disorders, such as tardive dyskinesia and neuroleptic malignant syndrome (NMS). ... 

Neuroleptic malignant syndrome (NMS) continues to be an unpredictable and rare - but potentially fatal - complication associated with the use of antipsychotic drugs (APDs)J ... 

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