Neural tissue repair

Rotterdam (79)studies, provide contradictory results. The presence of ApoE e4 allele(s) is associated with worse neurological impairment in head injury or stroke patients, suggesting that ApoE4 might actually impair neural tissue repair (80). 

Neural tissue repair in order to treat nerve damage or neuropathy arising from a spinal cord or cerebral injury essentially requires the intervention of tissue engineering because axons are unable to regenerate on their own. Hence, recent advances in neural tissue engineering provide suitable and promising substitutes... 

Ellis-Behnke, R., Schneider, G., and Zhang, S. Self-Assembling Peptides for Regeneration and Repair of Neural Tissue, 2004-968790 2005287186 (2005). 

Reier PJ, Anderson DK, Thompson EJ, Stokes BT (1992) Neural tissue transplantation and CNS trauma Anatomical and functional repair of the injured spinal cord. J Neurotrauma 9(Suppl 1 ) S223-248. 

Nerve grafts or conduits guide the repair of injured neural tissue. Neural repair in the central nervous system, as in the case of spinal injury, as well as peripheral nerve damage associated with trauma, often result in uncontrolled growth of neural tissue. The result is that no effective conduction path is obtained and both movement and sensory response can be lost in the body portion distal to the injury. 

Schmidt, C., Leach, J. Neural tissue engineering strategies for repair and regeneration. Rev. Biomed. Eng. 5, 293-347 (2003)... 

Repair Animal Models of Nervous System Injury Research Overall Summary of Neural Tissue Engineering References... 

Schmidt, CE and Leach, JB. 2003. Neural tissue engineering Strategies for repair and regeneration. Ann Rev Biomed Eng 5(l) 293-347. 

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