Neu5Ac

Acetamido-3,5-dicleoxy-D-g/ycero-a-D gafacfo-non-2-ulopyranosonic acid (W-acetyl-a-neuraminic acid, a-Neu5Ac), drawn in three ways (note that C-7 is the anomeric reference atom)... 

Cytidine 5 -(5-acetamido-3,5-dideoxy-D-g/ycero-P-D-ga/acto-non-2-ulopyranosylonic acid monophosphate) (CMP-p-Neu5Ac)... 

Fig. 1 A view of the influenza virus haemagglutinin (HA) monomer with the receptor fragment a-2,3-sialyUactose [a-Neu5Ac-(2,3)- 3-Gal-(1,4)-P-Glc] bound...

F%.2 A view of the influenza vims sialidase (NA) monomer with a-Neu5Ac 3a bound in the active site... 

The discovery of the potent in vitro sialidase inhibitory activity and in vivo efficacy of zanamivir 12, and the increasing availability of 3D structural data for influenza virus sialidases in the 1990s, particularly with Neu5Ac and various inhibitors bound into the active site, provided a platform for further drug discovery efforts targeting... 

Chan T-H, Xin Y-C, von Itzstein M (1997) Synthesis of phosphonic add analogs of siaUc acids (Neu5Ac and KDN) as potential sialidase inhibitors. J Org Chem 62 3500-3504 Chand P, Kotian PL, Dehghani A, El-Kattan Y, Lin T-H, Hutchison TL, Babu YS, Bantia S, Elliott AJ, Montgomery JA (2001) Systematic structure-based design and stereoselective synthesis of novel multisubstituted cyclopentane derivatives with potent antiinfluenza activity. J Med Chem 44 4379 392... 

Aldulosonic acids are involved in many important areas of glycobiology and glycomedicine, such as /V-acetylneuraminic acid (Neu5Ac), 3-deoxy-D-glycero-v-galacto-non-2- Aosonic acid (Kdn) and 3-deoxy-D-manno-oct-2-ulosonic acid (Kdo). 

Sialic acid Neu5Ac Flu virus Limax flavus 13-15... 

PAMAM-Chitosan 29a-e DS (NH2) Sialoside hybrid DS (Neu5Ac) Reactivity (%r... 

Finally, saponification of 26 followed by acid treatment (Dowex resin) afforded racemic NeuSAc, whose NMR spectrum (490 MHz) and chromatographic properties were identical with those of authentic NeuSAc. An efficient and stereoselective total synthesis of Neu5Ac had been accomplished as shown in Figure 6. 

UDP-a-D-Gal UDP-a-D-GlcNAc UDP-a-D-GalNAc GDP-a-D-Man GDP-P-l-Fuc CMP-Neu5Ac dTDP-a-D-Glc, dTDP-P-L-Rha combinatorial biocatalysis [32]... 

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