Neu5Ac analogs preparation

Table(2). Neu5Ac analogs prepared using Neu5Ac aldolase.

Other carbohydrate based analogues of zanamivir which have been synthesized as potential influenza virus sialidase inhibitors include the sulfur isostere (37), which was prepared from the known [113] 6-thio-Neu5Ac derivative (38) via a sequence analogous to that shown in Scheme 1.2 for the preparation of zanamivir [114]. The sulphur isostere (37) was found to have comparable activity (IC50 = 5 x 10 9 M) to zanamivir [114]. 

Therefore a series of analogous compounds, whose 2 anomeric carbon of Neu5Ac is left in the hemiacetalic structure, have been prepared to evaluate their affinity with the receptorial pocket, lacking of determined absolute configuration at the C-2 anomeric carbon. 

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