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Nesiritide Natrecor

Inamrinone (Inocor) Milrinone (Primacor) Nesiritide (Natrecor)... [Pg.41]

Nesiritide Natrecor (Scios/Innovex) Congestive heart failure... [Pg.276]

NESIRITIDE Nesiritide (natrecor), a recombinant form of human brain natriuretic peptide (BNP), is FDA-approved for treatment of dyspnea due to congestive heart failure. The natriuretic peptides—atrial natriuretic peptide (ANP), BNP, and C-type natriuretic peptide—are a family of endogenous hormones that possess potent natriuretic, diuretic, and vasodilator properties. BNP is secreted by ventricular cardiac myocytes in response to stretch circulating levels of BNP correlate with the severity of heart failure. In the setting of heart failure, the effects of BNP counteract the effects of Angll and NE by producing vasodilation, natriuresis, and diuresis. [Pg.571]

In addition to these traditional vasodilators, nesir-itide (Natrecor) was developed as a newer method for producing arterial and venous dilation in people with heart failure.58 This substance was derived from human B-type natriuretic peptide (BNP) using recombinant DNA techniques. BNP is a naturally occurring substance that is released from the ventricles when the heart is subjected to increased blood volume and pressure.12 This substance dilates peripheral arteries and veins, thus reducing cardiac afterload and preload, respectively. Hence, nesiritide can be administered intravenously to reduce cardiac workload in certain patients with severe or acute heart failure.12,58... [Pg.342]

Nesiritide. Summary Basis for Approval, Pharmacology Review, 2001. http //www. fda.gov/cder/foi/nda/2001/20-920 Natrecor.htm... [Pg.514]

Natrecor Nesiritide [synthetic analogue of human B-type natriuretic peptide (BNP)j 3.5 Sdos Congestive heart failure 107... [Pg.117]

Burger AJ, Horton DP, LeJemtel T, Ghali JK, Torre G, Dennish G, Koren M, Dinerman J, Silver M, Cheng ML, Elkayam U Prospective Randomized Evaluation of Cardiac Ectopy with Dobutamine or Natrecor Therapy. Effect of nesiritide (B-type natriuretic peptide) and dobutamine on ventricular arrhythmias in the treatment of patients with acutely decompensated congestive heart failure the PRECEDENT study. Am Heart J 2002 144(6) 1102-8. [Pg.1171]

USA nesiritide peptide Natrecor Noratak Recombinant human B-type natriuretic peptide, residues 1-32 Congestive heart failure... [Pg.480]

See other pages where Nesiritide Natrecor is mentioned: [Pg.318]    [Pg.234]    [Pg.336]    [Pg.666]    [Pg.234]    [Pg.1082]    [Pg.318]    [Pg.234]    [Pg.336]    [Pg.666]    [Pg.234]    [Pg.1082]    [Pg.320]    [Pg.1424]    [Pg.320]   
See also in sourсe #XX -- [ Pg.234 ]



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Natrecor

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