Nephrotoxicants with Similar Modes of Action

In a subsequent study, the additivity assumption (dose addition) was tested, using the similarly acting nephrotoxicants tetrachloroethylene, trichloroethylene, hexachloro-1,3-butadiene (HCBD), and l,l,2-trichloro-3,3,3-trifluoropropene (Jonker et al. 1996). The compounds were given to female rats by daily oral gavage for 32 days either alone, at the LONEL and NONEL (= LONEL/4), or in combinations of four (at the NONEL and LONEL/2) or three (at the LONEL/3) (see Table 10.9). 

Toxicological Studies of Chemicals with the Same Target Organ, the Kidney, but Different Modes of Action 

Compound (ppm in diet) (ppm In diet) (ppm In diet) Mode of Action 

Toxicological Risk Assessments of Chemicals A Practical Guide 

Four-Week Oral Toxicity Study in Female Rats with Mixtures of Nephrotoxicants Having Similar Modes of Action 

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