Neotripterifordin

Nicolaou, K.C., and Koide, K., Synthetic studies on maduropeptin chromophore. Part 1. Constmction of the aryl ether and attempted synthesis of the [7.3.0] bicyclic system. Tetrahedron Lett., 38, 3667, 1997. Corey, E.J., and Liu, K., Enantioselective total synthesis of the potent anti-HLV agent neotripterifordin. Reassignment of stereochemistry at C(16), J. Am. Chem. Soc., 119, 9929, 1997. 

In the course of the search for novel potent anti-AIDS agents, the ethanolic extract of the roots of T. wilfordii was found to show significant anti-HIV activity. Bioassay-directed fractionation of the active extract has led to the isolation and characterization of a new anti-HIV principle, a kaurane-type diterpene lactone, tripterifordin (90), Fig (27). This compound inhibited HIV replication in H9 lymphoc e cells with an EC50 of 1 pg/ml (6 (M) but it did not inhibit uninfected H9 cell growth at 15 xM [180]. From the same species a new kaurene type diterpene, neotripterifordin (91) was also isolated, which showed potent anti-HIV replication activity in H9 lymphocyte cells with an EC50 of 25 nM and a... 

Chen K, Shi Q, Fujioka T et al (1995) Anti-AIDs agents - XIX. Neotripterifordin, a novel anti-HIV principle from Tripterygium wilfordii isolation and structural elucidation. Bioorg Med Chem 3 1345-1348... 

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